Results 121 to 130 of about 648,885 (308)
Advanced Science, EarlyView.A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang +11 more
wiley +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Advanced Science, EarlyView.This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu +10 more
wiley +1 more source
A simple bivariate count data regression model [PDF]
This paper develops a simple bivariate count data regression model in which dependence between count variables is introduced by means of stochastically related unobserved heterogeneity components. Unlike existing commonly used bivariate models, we obtain
Shiferaw Gurmu, John Elder
core
Changes in the blood of infected dogs under different courses of parasitosis
Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні наукиGastrointestinal parasitoses are the most widespread invasions among dogs in different countries of the world. Their course varies considerably and depends on many factors, among which the type of invasion—caused by a single or multiple pathogens–is of ...
D. Kryvoruchenko
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng +6 more
wiley +1 more source
HAEMATOBIOCHEMICAL STUDIES IN DOGS AFFECTED WITH BACTERIAL DERMATITIS [PDF]
Journal of Veterinary and Animal Sciences, 2011 Infected group of dogs had significantly lower mean values of haemoglobin content, volume of packed red cells, total erythrocyte count and Iota! leucocyte count.
V. H. Shyma, K. Vijayakumar
doaj
Advanced Science, EarlyView.Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou +10 more
wiley +1 more source
ON BASELINE CONDITIONS FOR ZERO-INFLATED LONGITUDINAL COUNT DATA [PDF]
We describe a mixed-effects hurdle model for zero-inflated longitudinal count data, where a baseline variable is included in the model specification. Association between the count data process and the endogenous baseline variable is modeled through a ...
Valentina Raponi, Antonello Maruotti
core
Advanced Science, EarlyView.A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang +13 more
wiley +1 more source