Results 111 to 120 of about 78,012 (285)

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

Advanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui, Jingwei Wang, Xiaoyun Li, Lina Wang, Xuehan Mao, Rui Lyv, Wenqiang Yan, Jingyu Xu, Jieqiong Zhou, Chenxing Du, Shuhui Deng, Mu Hao, Yan Xu, Shuhua Yi, Dehui Zou, Tao Cheng, Xin Gao, Lugui Qiu, Gang An   +18 more
wiley   +1 more source

Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium

Haematologica, 2010
Background Abnormal adhesiveness of red blood cells to endothelium has been implicated in vaso-occlusive crisis of sickle cell disease. The present study examined whether the SAD mouse model exhibits the same abnormalities of red blood cell adhesion as ...
Marie-Marcelle Trinh-Trang-Tan, Camilo Vilela-Lamego, Julien Picot, Marie-Paule Wautier, Jean-Pierre Cartron   +4 more
doaj   +1 more source

Screening for microscopic hematuria in school-age children of the Gorgan city [PDF]

, 2014
Screening for hematuria was carried out in 3000 school-age children (6 to14 years old) in Gorgan, Iran, using a fresh morning urine sample. At the initial step, 208 (6.8%) had positive dipstick tests for blood, which decreased to 35 (1.2%) at the second ...
Abbasi, A., Meherkash, M., Moghtaderi, M., Noohi, A., Sabsechian, M., Safaeyan, B.   +5 more
core  

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling

Communications Biology
Neudesin, originally identified as a neurotrophic factor, has primarily been studied for its neural functions despite its widespread expression. Using 8-week-old neudesin knockout mice, we elucidated the role of neudesin in the spleen.
Yoshiaki Nakayama, Yuki Masuda, Takehiro Mukae, Tadahisa Mikami, Ryohei Shimizu, Naoto Kondo, Hiroshi Kitagawa, Nobuyuki Itoh, Morichika Konishi   +8 more
doaj   +1 more source

Integrating Deep Learning into Genotoxicity Biomarker Detection for Avian Erythrocytes: A Case Study in a Hemispheric Seabird

Mathematical and Computational Applications
Recently, nuclear abnormalities in avian erythrocytes have been used as biomarkers of genotoxicity in several species. Anomalous shapes are usually detected in the nuclei by means of microscopy inspection.
Martín G. Frixione, Facundo Roffet, Miguel A. Adami, Marcelo Bertellotti, Verónica L. D’Amico, Claudio Delrieux, Débora Pollicelli   +6 more
doaj   +1 more source

OSMOMETRIC BEHAVIOR OF NORMAL AND ABNORMAL HUMAN ERYTHROCYTES [PDF]

Blood, 1948
Abstract Normal human erythrocytes suspended in the series of hypotonic salt solutions employed for testing red cell fragility behave like nearly perfect osmometers throughout the series, with their maximum swelling, usually around 175 per cent of their initial volume, sharply defined by their mean surface area.
openaire   +2 more sources

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source