Results 61 to 70 of about 12,152 (258)

Viewpoint on handling anti-TNF failure in psoriasis [PDF]

, 2013
An association among the occurrence of antidrug antibodies (ADAs), diminished trough serum drug levels (TSDLs) and non-response or loss of response has been described for several tumor necrosis factor alpha (TNF) blocking agents in a variety of diseases,
BRACKE, STEFANIE, Lambert, Jo
core   +1 more source

Synergistic Efficacy of Chidamide and LB100 in Sézary Syndrome via TNC Downregulation and PI3K/AKT/mTOR Dephosphorylation

Cancer Science, EarlyView.
Chidamide combined with LB100 can effectively promote the death of Sézary Syndrome by inhibiting the expression of TNC and the phosphorylation of PI3K/AKT/mTOR. ABSTRACT Primary cutaneous T‐cell lymphoma (CTCL) manifests as a distinct variant of T‐cell non‐Hodgkin's lymphoma, predominantly impacting skin tissues and constituting approximately 75%–80 ...
Nan Chen, Yuan Wang, Lan Luo, Xin Hua, Qingfeng Xue, Beiqi Gong, Yaping Zhang, Wenyu Shi   +7 more
wiley   +1 more source

The phenotypic and genotypic spectra of ichthyosis with confetti plus novel genetic variation in the 3' end of KRT10: from disease to a syndrome [PDF]

, 2015
Ichthyosis with confetti (IWC) is a genodermatosis caused by dominant negative mutations in the gene encoding keratin 10 (KRT10). We investigated clinical and genetic details of a substantial number of patients with IWC in order to define major and minor
Brena, Michela, Burger, Bettina, De Mesmaeker, Julie, Fischer, Judith, Itin, Peter H., Schlipf, Nina, Spoerri, Iris, Tadini, Gianluca   +7 more
core   +1 more source

GWAS Identifies SNPs Associated With Severe Adverse Events and Efficacy in Advanced Renal Cell Carcinoma Treated With Nivolumab

Cancer Science, EarlyView.
This study highlights the importance of germline genetic markers in predicting severe trAEs caused by nivolumab. Our findings support their potential to guide personalized immunotherapy and improve treatment safety and efficacy in advanced ccRCC and other cancers.
Tokiyoshi Tanegashima, Masaki Shiota, Shusuke Akamatsu, Hideaki Miyake, Masayuki Takahashi, Mototsugu Oya, Norihiko Tsuchiya, Naoya Masumori, Hideyasu Matsuyama, Wataru Obara, Nobuo Shinohara, Kiyohide Fujimoto, Masahiro Nozawa, Kojiro Ohba, Chikara Ohyama, Katsuyoshi Hashine, Tomomi Kamba, Koji Mita, Momokazu Gotoh, Shuichi Tatarano, Masato Fujisawa, Yoshihiko Tomita, Shoichiro Mukai, Keiichi Ito, Shoji Tokunaga, Masatoshi Eto, SNiP‐RCC investigators   +26 more
wiley   +1 more source

Erythroderma

, 2018
Erythroderma, often described as generalized exfoliative dermatitis, is a condition in which erythema involves greater than 90% of the body surface, often as a result of an underlying inflammatory skin condition, which can result in a variety of systemic manifestations and potentially lead to life-threatening complications.
openaire   +1 more source

Клинические и патоморфологические критерии псориатической эритродермии [PDF]

, 2010
ДЕРМАТИТ ЭКСФОЛИАТИВНЫЙДЕРМАТОЛОГИЯПСОРИАЗЭРИТРОДЕРМИЯПредставлены результаты по клиническим и морфологическим признакам псориаза и псориатической эритродермии, а также эритродермиям иного генеза. Приведены дифференциально-диагностические таблицы и схема
Адаскевич, В. П., Мяделец, В. О.   +1 more
core  

Interleukin (IL)‐5, Eosinophils and IL‐5 Pathway Inhibitors in Eosinophilic Granulomatosis with Polyangiitis.

Arthritis &Rheumatology, Accepted Article.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Clinical and immunopathological spectrum of immunoglobulin M pemphigoid: a multicenter case series

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Pemphigoid diseases are primarily mediated by IgG or IgA autoantibodies against the cutaneous basement membrane zone (BMZ). Although recent observations suggest the existence of exclusively IgM‐mediated pemphigoid disease, a larger study is lacking.
Kaan Yilmaz, Stephanie Goletz, Christoph M. Hammers, Katharina Boch, Claudia Zeidler, Henning Wiegmann, Estelle Bergmann, Tina Rastegar Lari, Onur Dikmen, Nina Häring, Robert Strohal, Andreas Kleinheinz, Eva N. Hadaschik, Nina van Beek, Sonja Ständer, Enno Schmidt   +15 more
wiley   +1 more source

Erythrodermic Psoriasis with Superimposed Fungal Infection-a Presentation in the Emergency Room

Eurasian Journal of Emergency Medicine, 2018
Erythrodermic psoriasis or erythroderma is a life-threatening, generalized exfoliative dermatitis involving majority of the body surface. A detailed evaluation is required for the identification of its underlying cause to successfully treat and prevent ...
Muhammad Akbar Baig, Sadaf Sheikh
doaj   +1 more source

Expanding the Interface: Overlooked Dermatologic Disorders With Ocular Involvement

JEADV Clinical Practice, EarlyView.
A George
wiley   +1 more source