Screening of candidate analgesics using a patient-derived human iPSC model of nociception identifies putative compounds for therapeutic treatment. [PDF]
Clin Transl MedIn this study, Thornton and colleagues utilised an induced pluripotent stem cell (iPSC)‐based model of inherited erythromelalgia (IEM) to screen a library of 295 small molecules in search of potential pain‐modulating compounds. Their screening identified four compounds that significantly reduced spontaneous firing in iPSC‐derived nociceptor‐like cells,
Thornton JR +10 more
europepmc +2 more sources
Eltrombopag for the treatment of immune thrombocytopenia: The aegean region of Turkey experience [PDF]
, 2015 Objective: Immune thrombocytopenia (ITP) is an immune-mediated disease characterized by transient or persistent decrease of the platelet count to less than 100x109/L. Although it is included in a benign disease group, bleeding complications may be mortal.
Alacacıoğlu, İ. +21 more
core +4 more sources
Bromocriptine-associated ototoxicity [PDF]
, 2007 Three patients treated with bromocriptine for chronic hepatic encephalopathy showed audiometric evidence of bilateral sensori-neural hearing-loss. Audiometrically, the hearing improved in all three patients when the bromocriptine dosage was reduced, thus
Ballantyne, J, Lanthier, PL, Morgan, MY
core +1 more source
Immunohistochemical characterization of the 'intimal proliferation' phenomenon in Sneddon's syndrome and essential thrombocythaemia [PDF]
, 1994 Cellular changes were immunocytochemically characterized in skin vessels of five patients with idiopathic generalized racemose livedo (Sneddon's syndrome), and one patient with localized racemose livedo associated with essential thrombocythaemia ...
Jungkunz, W. +3 more
core +1 more source
Erythromelalgia: An Uncommon Presentation Precipitated by Aspirin Withdrawal
Case Reports in Medicine, 2012 Erythromelalgia is a rare disorder frequently associated with myeloproliferative disorders. We describe a case of elderly patient diagnosed with myeloproliferative disorder in remission.
Fatima Khalid +4 more
doaj +1 more source
Frontiers in Pediatrics, 2022 BackgroundPrimary erythrocytic (PEM) is a rare autosomal dominant single gene disease. Most of the changes of gene loci can be found by whole exon gene sequencing, and the clinical symptoms and patient survival can be improved by specific site-to-site ...
Shuo Feng +6 more
doaj +1 more source
Cutaneous pathology in primary erythermalgia [PDF]
, 1996 Primary or idiopathic erythermalgia is characterized by recurrent, red, warm, and painful lower extremities. It arises at young age and persists throughout life because no treatment is available. We report the cutaneous pathology of affected skin lesions
Casteels-Van Daele, M. (M.) +5 more
core +2 more sources
Pediatric-Isolated Auricular Erythromelalgia: A Case Report
Case Reports in Pediatrics, 2012 Erythromelalgia is a rare disorder that typically affects the skin of the feet, hands, or both, that is characterized by red skin, warmth, and a burning quality of pain. It usually affects both sides of the body, but may manifest unilaterally. Cooling of
Kelly Grandy, Gerard Corsten, Paul Hong
doaj +1 more source
Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7
Molecular Pain, 2007 Background The disabling chronic pain syndrome erythromelalgia (also termed erythermalgia) is characterized by attacks of burning pain in the extremities induced by warmth. Pharmacological treatment is often ineffective, but the pain can be alleviated by
Rush Anthony M +6 more
doaj +1 more source
A new TRPV3 missense mutation in a patient with Olmsted syndrome and erythromelalgia [PDF]
, 2014 IMPORTANCE: Olmsted syndrome (OS) is a rare keratinizing disorder characterized by excessive epidermal thickening of the palms and soles, with clinical and genetic heterogeneity.
Bodemer, Christine +7 more
core +1 more source