Results 41 to 50 of about 3,693 (191)

Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms [PDF]

, 2011
BACKGROUND: MicroRNA (miR) miR-34a, -34b/c, -124-1 and -203 are tumor suppressor miRs implicated in carcinogenesis. METHODS: We studied DNA methylation of these miRs in Philadelphia-negative (Ph-ve) myeloproliferative neoplasms (MPNs).
Chim, CS, Drexler, HG, Fung, TK, Wan, TS, Wong, KF, Wong, KY   +5 more
core   +1 more source

Late-onset erythromelalgia in a previously healthy young woman: a case report and review of the literature

Journal of Medical Case Reports, 2009
Introduction Erythromelalgia is a rare disorder characterized by episodic erythema and burning pain, which commonly involves the extremities. We present a case of late onset erythromelalgia in a previously healthy young woman and briefly review the ...
Gaur Shobhana, Koroscil Thomas
doaj   +1 more source

Palmo-plantar keratoderma with debilitating pruritus

Indian Journal of Paediatric Dermatology, 2020
We describe two siblings with diffuse, mutilating palmo-plantar keratoderma suggestive of Olmsted syndrome, with significantly compromised quality of life in the form of inability to walk and grasp objects.
Vandana Kataria, Chander Grover, Deepika Pandhi   +2 more
doaj   +1 more source

Association between systemic sclerosis, palmar fasciitis with polyarthritis, Raynaud’s phenomenon and erythromelalgia with underlying malignancy

Rheumatology, 2022
The symptoms of a rheumatic disease may also be a sign of a proliferative process. These include conditions that present with skin and vascular changes such as systemic sclerosis and Raynaud’s phenomenon with peripheral ischaemia and ulceration ...
Katarzyna Nowak, Gary Wright
doaj   +1 more source

SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing. [PDF]

PLoS ONE, 2016
Gain-of-function mutations in the tetrodotoxin (TTX) sensitive voltage-gated sodium channel (Nav) Nav1.7 have been identified as a key mechanism underlying chronic pain in inherited erythromelalgia.
Andreas M Kist, Dagrun Sagafos, Anthony M Rush, Cristian Neacsu, Esther Eberhardt, Roland Schmidt, Lars Kristian Lunden, Kristin Ørstavik, Luisa Kaluza, Jannis Meents, Zhiping Zhang, Thomas Hedley Carr, Hugh Salter, David Malinowsky, Patrik Wollberg, Johannes Krupp, Inge Petter Kleggetveit, Martin Schmelz, Ellen Jørum, Angelika Lampert, Barbara Namer   +20 more
doaj   +1 more source

Successful use of phlebotomy to treat severe secondary polycythemia due to chronic lung disease

Hematology Reports, 2021
Secondary polycythemia (SP) occurs as a result of increase erythropoietin levels most commonly as a result of tissue hypoxia. Symptoms such as erythromelalgia, pruritis, and bleeding, which are frequently seen in polycythemia vera (PV), do not commonly ...
Jacob Fuqua, Josephine Reece, Sarah Sofka   +2 more
doaj   +1 more source

Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia [PDF]

, 2008
3openA.
Ania, Campbell, Cortelazzo, Cortelazzo, Egger, Finazzi, Finelli, Harrison, Higgins, Higgins, Landolfi, Landolfi, Landolfi, Lau, Maclure, Marchioli, Mesa, Parmar, Passamonti, Rocca, Tartaglia, Vardiman   +21 more
core   +1 more source

Dual Effect of Ziconotide in Primary Erythromelalgia

Case Reports in Medicine, 2015
Erythromelalgia (EM) is a rare disabling clinical syndrome more commonly known to affect the lower extremities. There is no single effective treatment for this disease that often requires a multidisciplinary approach.
Rosario Russo, Maria Cristina Caroleo, Erika Cione, Mariarita Perri, Maria Teresa Paparo, Antonio Russo   +5 more
doaj   +1 more source

Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]

, 2018
BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
core  

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. [PDF]

, 2016
Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. However, defining the Nav1.7 contribution to nociceptive signalling has been hampered by a lack of selective inhibitors.
Alexandrou, AJ, Brown, AR, Butt, RP, Castle, NA, Chapman, ML, Cox, PJ, Dib-Hajj, SD, Doyle, R, Estacion, M, Gutteridge, A, Hounshell, JA, Krafte, D, Lin, Z, Marron, BE, Mis, MA, Patel, MK, Payne, EC, Printzenhoff, D, Randall, A, Rivara, M, Stevens, EB, Storer, RI, Stupple, PA, Swain, NA, Turner, J, Waxman, SG, West, C, Wilbrey, A   +27 more
core   +1 more source