Results 61 to 70 of about 3,693 (191)

Using internet search data to predict new HIV diagnoses in China: a modelling study. [PDF]

, 2018
ObjectivesInternet data are important sources of abundant information regarding HIV epidemics and risk factors. A number of case studies found an association between internet searches and outbreaks of infectious diseases, including HIV. In this research,
Chai, Yi, Li, Xiaoming, Young, Sean D, Zhang, Qingpeng, Zhou, Jiaqi   +4 more
core   +3 more sources

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief [PDF]

, 2016
INTRODUCTION: Chronic pain is a massive clinical problem. We discuss the potential of subtype selective sodium channel blockers that may provide analgesia with limited side effects.
Emery, EC, Luiz, AP, Wood, JN
core   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
wiley   +1 more source

Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations. [PDF]

, 2015
The importance of NaV1.7 (encoded by SCN9A) in the regulation of pain sensing is exemplified by the heterogeneity of clinical phenotypes associated with its mutation.
Cox, James J, Emery, Edward C, Gribble, Fiona M, Habib, Abdella M, Nicholas, Adeline K, Reimann, Frank, Woods, C Geoffrey   +6 more
core   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, Volume 599, Issue 12, Page 1717-1732, June 2025.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Functionalized Polydopamine Nanoparticles: A Promising Drug Delivery Platform for the Treatment of Tuberculosis

Drug Development Research, Volume 86, Issue 4, June 2025.
ABSTRACT Tuberculosis (TB) is considered a major infectious disease by the World Health Organization. The WHO estimates that there are 1.8 million TB deaths, and 10.4 million new cases of the disease reported yearly. While there are conventional therapies for TB, they have drawbacks such as a lengthy pill regimen, rigorous scheduling, and protracted ...
Nnamdi Ikemefuna Okafor, Precious Nnaji, Ngozi Francisca Nnolum‐Orji, Yahya E. Choonara   +3 more
wiley   +1 more source

Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia [PDF]

, 2017
Automated patch clamp (APC) technology was first developed at the turn of the millennium. The increased throughput it afforded promised a new paradigm in ion channel recordings: it offered the potential to overcome the time-consuming, low-throughput ...
Alexander, Alexander, Alexander, Alexander, Alexandrou, Arias, Asmild, Bagal, Becker, Bridgland-Taylor, Brinkwirth, Brüggemann, Cao, Castle, Chambard, Chambers, Dale, Danker, Deuis, Dunlop, Dunlop, Enna, Estacion, Fertig, Finkel, Friis, Gilbert, Gillie, Golden, Hamill, Hao, Haraguchi, Haythornthwaite, Ji, Kahle, Kao, Kauthale, Klement, Klint, Knabl, Kornecook, Kumar, Kuryshev, Lepple-Wienhues, Lin, Mathes, Mathes, Mathie, Miller, Milligan, Obergrussberger, Obergrussberger, Papakosta, Payne, Perkel, Sakmann, Sauter, Scheel, Schroeder, Shcherbatko, Shcherbatko, Sorota, Southan, Southan, Spencer, Stannard, Stoelzle, Swensen, Tao, Terstappen, Tibbs, Trivedi, Vasilyev, Windley, Xie, Xu, Xu   +76 more
core   +1 more source

THE ANGIOTROPHONEUROSES. ERYTHROMELALGIA IN A 11-YEAR OLD CHILD

Alʹmanah Kliničeskoj Mediciny, 2016
The article deals with angiotrophoneuroses, a large group of heterogenous disorders with an underlying dysfunction of vascular innervation. A  current classification of vegetovascular neuroses, their triggers and clinical manifestations are described. The
O. B. Tamrazova, A. V. Molochkov, O. V. Koren'kova, K. A. Novikov   +3 more
doaj   +1 more source

Angiitis with Nodule Formation, Vasomotor Instability and Secondary Cutis Laxa11From the University of Southern California School of Medicine, Department of Medicine (Doctor Winsor) and Section of Dermatology (Doctor Obermayer), Los Angeles, California. [PDF]

, 1959
https://nsuworks.nova.edu/nsudigital_harrison/3625/thumbnail ...
Obermayer, Maximilian E., Winsor, Travis
core   +1 more source