Results 71 to 80 of about 166,556 (323)

Erythromycin as a safe and effective treatment option for erythema annulare centrifugum

Indian Journal of Dermatology, 2015
Background: Erythema annulare centrifugum (EAC) is an inflammatory dermatosis with unknown etiology. It is usually self-limited, but chronic disease may be difficult to treat.
Fu-Chen Chuang, Shang-Hong Lin, Wei-Ming Wu   +2 more
doaj   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Severe pertussis infection in infants less than 6 months of age: clinical manifestations and molecular characterization [PDF]

, 2017
We conducted a study to determine the main traits of pertussis among unimmunized infants less than 6 months of age. From August 2012 to March 2015, 141 nasopharyngeal aspirates (NPAs) were collected from infants with respiratory symptoms attending 2
Buttinelli, Gabriele, Carsetti, Rita, Concato, Carlo, Di Mattia, Greta, Fedele, Giorgio, Gesualdo, Francesco, Midulla, Fabio, Nicolai, Ambra, Stefanelli, Paola, the Pertussis Study Group,, Tozzi, Alberto E., Vacca, Paola, Villani, Alberto   +12 more
core   +1 more source

Real‐World Edoxaban Concentrations in Older Patients Receiving Reduced‐Dose Regimens

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world edoxaban concentrations in older patients receiving reduced‐dose regimens. Low trough concentrations (< 12 ng/mL) were associated with an increased risk of thromboembolism. Among patients meeting the ELDERCARE‐AF criteria, low drug levels were more frequent with the 15 mg regimen than with the 30 mg regimen.
Sung‐Chun Tang, Shin‐Yi Lin, Chih‐Hao Chen, Yen‐Bin Liu, Li‐Ting Ho, Ching‐Hua Kuo, Yu‐Fong Peng, Chih‐Fen Huang, Jiann‐Shing Jeng   +8 more
wiley   +1 more source

Inducible and constitutive clindamycin resistance in Staphylococcus aureus in a northeastern Indian tertiary care hospital

Journal of Infection in Developing Countries, 2015
Introduction: Staphylococcus aureus is one of the most common pyogenic bacteria. They are notorious for developing prompt resistance to newer antimicrobials. With increasing incidence of methicillin-resistant S.
Amit Banik, Annie Bakorlin Khyriem, Jeetendra Gurung, Valarie Wihiwot Lyngdoh   +3 more
doaj   +1 more source

Antimicrobial susceptibility of Neisseria gonorrheae strains in three regions of Armenia [PDF]

, 2007
OBJECTIVE: There are no data available on gonococcal susceptibility in the Caucasus region. We aimed to determine in vitro antimicrobial susceptibility of Neisseria gonorrheae in Armenia in order to update the national treatment protocol.
Borisenko, Clayes, Dorlencourt, Fenton, Singour, Vereshchagin, Waugh   +6 more
core   +2 more sources

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

The Immunomodulatory Effects of Macrolides—A Systematic Review of the Underlying Mechanisms

Frontiers in Immunology, 2018
BackgroundThe mechanisms underlying the non-antimicrobial immunomodulatory properties of macrolides are not well understood.ObjectivesTo systematically review the evidence for the immunomodulatory properties of macrolides in humans and to describe the ...
Petra Zimmermann, Petra Zimmermann, Petra Zimmermann, Petra Zimmermann, Victoria C. Ziesenitz, Nigel Curtis, Nigel Curtis, Nigel Curtis, Nicole Ritz, Nicole Ritz, Nicole Ritz   +10 more
doaj   +1 more source

Investigating the removal of some pharmaceutical compounds in hospital wastewater treatment plants operating in Saudi Arabia [PDF]

, 2016
The concentrations of 12 pharmaceutical compounds (atenolol, erythromycin, cyclophosphamide, paracetamol, bezafibrate, carbamazepine, ciprofloxacin, caffeine, clarithromycin, lidocaine, sulfamethoxazole and Nacetylsulfamethoxazol (NACS)) were ...
Akunna, Joseph C., Al Qarni, Hamed M., Collier, Phillip, O'Keeffe, Juliette   +3 more
core   +3 more sources

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source