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British Medical Bulletin, 1989
Erythropoietin mRNA is detected primarily in kidney peritubular cells in response to hypoxia, and this tissue is the major adult source of the hormone. Erythropoietin can be assayed by in vivo or in vitro biological methods, or by radioimmunoassay, but only the in vivo assay can distinguish the most biologically active forms.
E D, Zanjani, J L, Ascensao
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Erythropoietin mRNA is detected primarily in kidney peritubular cells in response to hypoxia, and this tissue is the major adult source of the hormone. Erythropoietin can be assayed by in vivo or in vitro biological methods, or by radioimmunoassay, but only the in vivo assay can distinguish the most biologically active forms.
E D, Zanjani, J L, Ascensao
+9 more sources
Erythropoietin and Erythropoietin Receptor
Growth Factors, 1999(1999). Erythropoietin and Erythropoietin Receptor. Growth Factors: Vol. 17, No. 1, pp. 25-35.
P A, Tilbrook, S P, Klinken
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Comprehensive Physiology, 2011
AbstractThe hormone erythropoietin (Epo) is the main humoral regulator of erythropoiesis. It binds to specific receptors belonging to the cytokine receptor superfamily. Epo stimulates proliferation and differentiation of erythroid precursor cells, but may also bind to and exert some additional effects in nonhemopoietic tissues. It is mainly produced in
Wenger, R H, Kurtz, A
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AbstractThe hormone erythropoietin (Epo) is the main humoral regulator of erythropoiesis. It binds to specific receptors belonging to the cytokine receptor superfamily. Epo stimulates proliferation and differentiation of erythroid precursor cells, but may also bind to and exert some additional effects in nonhemopoietic tissues. It is mainly produced in
Wenger, R H, Kurtz, A
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Leukemia Research, 1990
The remarkable capacity of the bone marrow to compensate for blood loss and for reduced atmospheric oxygen tension has been found to be mediated by a renal hormone, named erythropoietin. It is produced by peritubular interstitial cells in response to renal hypoxia, but molecular engineering has permitted large scale production of an identical ...
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The remarkable capacity of the bone marrow to compensate for blood loss and for reduced atmospheric oxygen tension has been found to be mediated by a renal hormone, named erythropoietin. It is produced by peritubular interstitial cells in response to renal hypoxia, but molecular engineering has permitted large scale production of an identical ...
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Erythropoietin and Erythropoietin Receptor in Colorectal Cancer
International Journal of Surgical Pathology, 2008Erythropoietin via erythropoietin receptor effectively prevents anemia, giving reasons for a clinical use of erythropoietin in patients with colorectal cancers. However, erythropoietin seems to promote survival of the neoplastic cells in hypoxic environment.
Anna M, Chabowska +5 more
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Journal of Endocrinological Investigation, 2003
This article summarizes recent advances in understanding the production and action of the hormone erythropoietin (Epo) with respect to high altitude physiology and sports medicine. Hypoxia is the main stimulus for Epo gene expression. An O2-labile protein (hypoxia-inducible factor 1, HIF-1) has been identified that is hydroxylated and degraded under ...
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This article summarizes recent advances in understanding the production and action of the hormone erythropoietin (Epo) with respect to high altitude physiology and sports medicine. Hypoxia is the main stimulus for Epo gene expression. An O2-labile protein (hypoxia-inducible factor 1, HIF-1) has been identified that is hydroxylated and degraded under ...
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Pediatrics, 1959
ERYTHROPOIETINE is a protein, capable of stimulating erythrocyte production, which is found in the plasma of animals subjected to hypoxia or following the administration of cobalt. Sufficient data have been accumulated in the more common hematologic disorders to draw some tentative conclusions about its etiologic and therapeutic significance in ...
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ERYTHROPOIETINE is a protein, capable of stimulating erythrocyte production, which is found in the plasma of animals subjected to hypoxia or following the administration of cobalt. Sufficient data have been accumulated in the more common hematologic disorders to draw some tentative conclusions about its etiologic and therapeutic significance in ...
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Down with the Erythropoietin. Long Live the Erythropoietin !
Current Drug Targets, 2009In recent years the use of erythropoietin has exploded, and the anaemia of patients with chronic renal failure has been practically resolved with the administration of rHuEpo (recombinant human, Erythropoietin). However, as a result of an intense commercial campaign, strong therapies with this growth hormone, prescribed to achieve surprising sporting ...
BUEMI, Michele +8 more
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