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The human erythropoietin receptor
The International Journal of Cell Cloning, 1992Molecular analysis of the human erythropoietin receptor (EpoR) promises to yield a greater mechanistic understanding of erythropoiesis and disease states that affect red cell production. The cloned receptor molecule is a 66 kDa membrane protein that is structurally related to a large superfamily of haemopoietin/growth factor receptors.
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Physiology and function of the erythropoietin receptor
Current Opinion in Hematology, 1998Interaction between erythropoietin (EPO) and its membrane receptor induces the proliferation and differentiation of erythroid progenitors. Targeted disruption of the EPO receptor (EPOR) gene have clearly demonstrated the importance of the EPO/EPOR system for definitive erythroid cell survival and proliferation; however, in vitro rescue experiments have
A, Yoshimura, H, Misawa
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1995
Abstract Epo receptors are detectable in binding experiments using 125I-epo. Primary erythroid progenitors in the yolk sac, fetal liver, bone marrow and spleen express small numbers of receptors, as do megakaryocytes (300-1000 per cell) (Youssoufian et al. 1993).
D J Hilton, S S Watowich
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Abstract Epo receptors are detectable in binding experiments using 125I-epo. Primary erythroid progenitors in the yolk sac, fetal liver, bone marrow and spleen express small numbers of receptors, as do megakaryocytes (300-1000 per cell) (Youssoufian et al. 1993).
D J Hilton, S S Watowich
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The role of erythropoietin and erythropoietin receptor in malignant laryngeal tumors
Medical Hypotheses, 2013Erythropoietin (Epo) is a glycoprotein hormone responsible for erythropoiesis. Its effect is realized by binding erythropoietin receptor (EpoR) expressed on erythroid progenitor cells. Hypoxia is the main stimulus for the secretion of erythropoietin. Anemia is an independent negative prognostic factor for survival in patients with malignant diseases ...
Vukelić, Jelena +4 more
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Activation and inhibition of the erythropoietin receptor by a membrane-anchored erythropoietin
Experimental Hematology, 2008To investigate whether expression of a membrane-anchored form of erythropoietin (MbEpo) results in self-controlled, autocrine proliferation, and differentiation of erythroid cells. This would provide a possible approach to the selective expansion of genetically corrected erythroid cells in gene-therapy protocols.We designed retroviral vectors encoding ...
Olivier, Negre +6 more
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Erythropoietin Receptor Structural Domains
2017Erythropoietin (EPO) is a hormone that is important for regulating red blood cell production. It is functional through binding to its receptor-EpoR. EpoR is a single-span membrane protein. It contains an extracellular region, a transmembrane domain, and a C-terminus.
Qingxin, Li, CongBao, Kang
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Erythropoietin and erythropoietin receptor expression in normal and disturbed pregnancy
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2008Erythropoietin (Epo) is known to regulate the number of circulating erythrocytes. Epo receptor (Epo-R) expression is limited to few organs including the uterus. We investigated differences in Epo and Epo-R expression in normal and disturbed first trimester human pregnancy.Placental tissue was obtained from normal human pregnancy, abortion and ...
Bettina, Toth +5 more
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Blood, 1999
Erythropoietin (EPO) is required for the survival and expansion of red blood cell progenitor cells and supports continued differentiation of these committed progenitors to mature red blood cells. After binding to its cognate receptor, EPO promotes receptor homodimerization, activation of receptor-associated JAK2, subsequent receptor tyrosine ...
D L, Beckman +3 more
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Erythropoietin (EPO) is required for the survival and expansion of red blood cell progenitor cells and supports continued differentiation of these committed progenitors to mature red blood cells. After binding to its cognate receptor, EPO promotes receptor homodimerization, activation of receptor-associated JAK2, subsequent receptor tyrosine ...
D L, Beckman +3 more
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Expression of Erythropoietin and Erythropoietin Receptor in Human Dental Pulp
Journal of Endodontics, 2010In addition to the involvement in erythropoiesis, erythropoietin (EPO) and its receptor (EPO-R) have been shown to be expressed in various nonhematopoietic organs and tissues with diverse biological effects. The purpose of this study was to evaluate the expression patterns of EPO and EPO-R in healthy and inflamed human dental pulp tissues.
Qimei, Gong +4 more
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The molecular physiology of erythropoietin and the erythropoietin receptor.
Current opinion in hematology, 1999Erythropoietin is the major glycoprotein hormone regulator of mammalian erythropoiesis. Erythropoietin is secreted by the kidney in response to decreased blood oxygen. It circulates in the blood, and binds and activates a specific receptor expressed on bone marrow erythroblasts.
Y, Zhu, A D, D'Andrea
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