Results 241 to 250 of about 804,660 (312)

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Computational mechanisms for temporal integration in the anterior claustrum. [PDF]

Elife
Sohn K, Yoon D, Lee J, Choi S.
europepmc   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Immersive learning in quality improvement: evaluating a virtual reality escape room for medical learners and faculty. [PDF]

BMC Med Educ
Weagle R, Venables MJ, Jolin-Dahel K.
europepmc   +1 more source

Metal‐Support Interaction Triggered Electronic Reconstruction in Pd/CoN‐Co4N Catalysts for Optimizing MEK Oxidation and Poisoning Resistance

Advanced Science, EarlyView.
The strengthened EMSI in Pd/CoN‐Co4N induces electronic rearrangement, generating abundant Pd0 species in situ, modulating the Pd d‐band center to enhance O2 adsorption and MEK activation. Concurrently, it creates numerous Lewis acid sites that preferentially adsorb poisons and shield the active sites.
Yadi Wang, Chaoqian Ai, Cai Wang, Zeyu Jiang, Jialei Wan, Jingjing Wang, Xiangbo Feng, Chi He   +7 more
wiley   +1 more source

Digital escape rooms in medical education: Lessons learned from design and pilot implementation. [PDF]

BMC Med Educ
Tekin M, Korkmaz G, Kılınçarslan MG, Toraman Ç, Tekeş E, Çelik T, Akar SGM, Alakurt T, Saygılı ES, Alimoğlu MK, Yurdal MO, Akdikmen Y.   +11 more
europepmc   +1 more source

Progress in immunotherapy for <i>Helicobacter pylori</i> infections. [PDF]

Front Cell Infect Microbiol
Zhong W, Yang Y, Cao P, Luo LX, Wang K.
europepmc   +1 more source

From Complete Heart Block to Torsades de Pointes: An Axis to Remember. [PDF]

JACC Case Rep
Mystakidi VC, Pantelidis P, Gerostathis A, Dilaveris PE, Siasos G.   +4 more
europepmc   +1 more source

Effectiveness of escape room-based learning for patient safety education in nursing students. [PDF]

BMC Med Educ
Demet I, Demet S, Kübra T, Rukiye K.
europepmc   +1 more source

Core regulatory mechanisms of the PD-L1 axis and clinical strategies for immune escape and immunotherapy response in nasopharyngeal carcinoma. [PDF]

Transl Oncol
Li H, Yang M, Li D, Wang C.
europepmc   +1 more source