Results 201 to 210 of about 871,454 (260)

Impulsivity facets and internet gaming disorder symptoms in male adolescents with ADHD: an exploratory cross-sectional study from Turkiye. [PDF]

BMC Psychiatry
İçen S, Karaca Cengiz ŞN.
europepmc   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Simultaneous Mars-orbit observations reveal Kelvin-Helmholtz instability-driven bulk atmospheric ion escape. [PDF]

Sci Adv
Zhang C, Dong C, Poh G, Halekas J, Ma X, Suranga R, Hanley KG, Shen HW, Zhou H, Li X, Wang L, Gao J, Curry S, Mazelle C.   +13 more
europepmc   +1 more source

Probabilistic Computing via Gate‐Tunable Random Telegraph Noise

Advanced Science, EarlyView.
Intrinsic random telegraph noise in metal–oxide–semiconductor field‐effect transistors is harnessed to create gate‐tunable probabilistic bits. By modulating carrier‐trapping dynamics, the device produces stochastic binary outputs with a continuous bias‐to‐probability transfer.
Gyungwon Yun, Jin Pyo Kang, Ho‐Sung Lee, Ik‐Hyeon Jeon, Ki‐Ju Park, Won‐Ju Cho, Seung‐heon Chris Baek, Joo‐Hyung Chae, Hamin Park   +8 more
wiley   +1 more source

Gratification vs. compensation: longitudinal evidence for the shifting motivations behind adolescent gaming disorder. [PDF]

Front Psychiatry
Starzec S, Zajas A, Michałkiewicz N, Kiszka P, Kowalska L, Strojny P.   +5 more
europepmc   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Coupled SDE-ODE Modeling of Tumor-Immune Dynamics to Infer Biomarker Release. [PDF]

Bull Math Biol
Shrestha P, Fan Y, George JT.
europepmc   +1 more source

WGM Single‐Molecule Validation of pH‐Dependent Molecular Energetics at Gold Nanointerfaces: Influence of Buffer Molecules on Glyphosate Ligand Binding

Advanced Science, EarlyView.
Single‐molecule optical sensing reveals how pH and buffer molecules regulate glyphosate interactions with gold nanorods. Combined experiments and theoretical calculations show that changes in molecular charge and competition from buffer species determine whether glyphosate binds transiently or persistently.
Kulathunga Mudalige Kalani Perera, Srikanth Pedireddy, Sivaraman Subramanian, Frank Vollmer   +3 more
wiley   +1 more source