Results 41 to 50 of about 37,998 (252)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Printed in U.S.A. AN ESCAPE-TIME CRITERION FOR QUEUEING NETWORKS: ASYMPTOTIC RISK-SENSITIVE CONTROL [PDF]
, 2008 We consider the problem of risk-sensitive control of a stochastic network. In controlling such a network, an escape-time criterion can be useful if one wishes to regulate the occurrence of large buffers and buffer overflow. In this paper a risk-sensitive
Rami Atar +3 more
core
AxiomsIn this article, we examine and investigate various variants of Julia set patterns for complex exponential functions W(z)=αezn+βzm+logct, and T(z)=αezn+βzm+γ (which are analytic except at z=0) where n≥2, m,n∈N, α,β,γ∈C,c∈C∖{0} and t∈R,t≥1, by employing a
Ahmad Almutlg, Iqbal Ahmad
doaj +1 more source
Usability evaluation of mechatronic system by primary school children [PDF]
MATEC Web of Conferences, 2020 The paper examines the ease of use of a mechatronic system by children aged 7-12+ years living in the area of Thessaloniki. The research was conducted on students who participated in educational robotics seminars and as the results show, the trainees ...
Chatzikyrkou Maria
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Large-Scale Expensive Optimization with a Switching Strategy
Complex System Modeling and Simulation, 2022 Some optimization problems in scientific research, such as the robustness optimization for the Internet of Things and the neural architecture search, are large-scale in decision space and expensive for objective evaluation.
Mai Sun +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Fractal and FractionalThis study presents an innovative iterative method designed to approximate common fixed points of generalized contractive mappings. We provide theorems that confirm the convergence and stability of the proposed iteration scheme, further illustrated ...
Khairul Habib Alam +5 more
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From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source