Results 41 to 50 of about 871,454 (260)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

On the Application of Mann-Iterative Scheme with h-Convexity in the Generation of Fractals

Fractal and Fractional
Self-similarity is a common feature among mathematical fractals and various objects of our natural environment. Therefore, escape criteria are used to determine the dynamics of fractal patterns through various iterative techniques. Taking motivation from
Asifa Tassaddiq, Muhammad Tanveer, Muhammad Zubair, Muhammad Arshad, Carlo Cattani   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Escape-strategy data

, 2017
Escape behavior data ( FID and flight distance) of grasshoppers in a urban ...
Pim Edelaar (645112), Adrián Baños-Villalba (3664528), David P. Quevedo (5015759), Baños-Villalba, Adrián, Edelaar, Pim, Quevedo, David P.   +5 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Fractals as Julia Sets for a New Complex Function via a Viscosity Approximation Type Iterative Methods

Axioms
In this article, we examine and investigate various variants of Julia set patterns for complex exponential functions W(z)=αezn+βzm+logct, and T(z)=αezn+βzm+γ (which are analytic except at z=0) where n≥2, m,n∈N, α,β,γ∈C,c∈C∖{0} and t∈R,t≥1, by employing a
Ahmad Almutlg, Iqbal Ahmad
doaj   +1 more source

Large-Scale Expensive Optimization with a Switching Strategy

Complex System Modeling and Simulation, 2022
Some optimization problems in scientific research, such as the robustness optimization for the Internet of Things and the neural architecture search, are large-scale in decision space and expensive for objective evaluation.
Mai Sun, Chaoli Sun, Xiaobo Li, Guochen Zhang, Farooq Akhtar   +4 more
doaj   +1 more source

Visualizations of Q-criterion

, 2021
Visualizations of time-varying Q-criterion for each of the ruptured/unruptured pairs listed in Table 3. Q-criterion isosurfaces (i.e., vortex cores) at Q=1.5 are colour-coded by velocity magnitude, per legend at upper right.
David Steinman (8588424)
core   +1 more source