Results 221 to 230 of about 386,523 (355)

The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma.

Journal of Clinical Investigation, 2013
B. Parker, Matti Annala, D. Cogdell, Kirsi J. Granberg, Yan Sun, P. Ji, Xia Li, J. Gumin, Hong Zheng, Limei Hu, O. Yli-Harja, H. Haapasalo, T. Visakorpi, Xiuping Liu, Chang-gong Liu, R. Sawaya, G. Fuller, Kexin Chen, F. Lang, M. Nykter, Wei Zhang   +20 more
semanticscholar   +1 more source

The exposed glottis paradox: Spontaneous ventilation-assisted trans-wound intubation in complete translaryngeal transection. [PDF]

Indian J Anaesth
Goyal A, Panigrahi P, Singla K, Jain K.
europepmc   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic-Like Behaviors. [PDF]

Adv Sci (Weinh)
Barcelon E, Noh K, Hwang M, Kim YJ, Lee U, Ryu YJ, Ryu JK, Jun SB, Choi SY, Cho WH, Lee SJ.   +10 more
europepmc   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

From metaphor to metric: the entropic framework as a unifying theory of aging. [PDF]

Life Med
Chen Y, Mao Z.
europepmc   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Revisiting water-in-salt electrolytes with ionic liquid incorporation through high-resolution liquid-structure mapping. [PDF]

Natl Sci Rev
Yang Z, Liu X, Zhao D, Chao D.
europepmc   +1 more source

Engineering an Optogenetic pH‐Modulator in Bacteria

Advanced Science, EarlyView.
ABSTRACT Cells in many naturally occurring organisms routinely cooperate to control their extracellular pH in a dynamic and reversible manner, but this capability has been underexplored in synthetic biology. Here, we sought to engineer a microbial system that switches between two states —high and low extracellular pH— with minimal human intervention ...
Jenevieve Kuang, Olivia J. Armendarez, Wei‐Ting Chang, Matthew M. Hausladen, Shanna Bonanno, Daniel J. Wilson, Neel S. Joshi, Leila F. Deravi   +7 more
wiley   +1 more source

Molecular characterization of Serrasalmidae hybrid in the upper Paraná River floodplain using molecular markers. [PDF]

J Fish Biol
Ramos LI, de Páris Paz E, Cavalcanti LD, Takemoto RM, de Oliveira AV.   +4 more
europepmc   +1 more source