Results 111 to 120 of about 495,730 (356)

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]

, 2007
Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad, Dryselius, Rikard, Faridani, Omid R, Ganyu, Anita, Goh, Shan, Good, Liam, Klok, Erik Jan, Nikravesh, Abbas, Sadeghizadeh, Majid, Zain, Rula   +9 more
core   +2 more sources

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Oral phage therapy with microencapsulated phage A221 against Escherichia coli infections in weaned piglets. [PDF]

BMC Vet Res, 2023
Mao X, Wu Y, Ma R, Li L, Wang L, Tan Y, Li Z, Liu H, Han K, Cao Y, Li Y, Peng H, Li X, Hu C, Wang X.   +14 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Risk Factors for Non-O157 Shiga Toxin-Producing Escherichia coli Infections, United States. [PDF]

Emerg Infect Dis, 2023
Marder EP, Cui Z, Bruce BB, Richardson LC, Boyle MM, Cieslak PR, Comstock N, Lathrop S, Garman K, McGuire S, Olson D, Vugia DJ, Wilson S, Griffin PM, Medus C.   +14 more
europepmc   +1 more source

Prevention of enteroxigenic Escherichia coli infections in pigs by dairy-based nutrition [PDF]

, 2015
Postweaning diarrhea (PWD) is a significant enteric disease causing considerable economic losses for the pig industry. Among several aetiological risk factors, enterotoxigenic Escherichia coli (ETEC) is considered to be a major cause.
Jensen, BB, Jensen, KH, Lauridsen, C, Sugiharto, Sugiharto   +3 more
core  

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

The Relationship between Phylogenetic Groups and Pathogenicity Encoding Genes with regards to Extra-Intestinal Escherichia coli Isolates’ Factors using Multiplex-PCR Method

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2015
BACKGROUND AND OBJECTIVE: Extraintestinal Escherichia coli bacteria is the main reason behind the urogenital infections in humans. Several virulence factors such as cytotoxin genes coding for proteins, adhesion, siderophore receptors and outer-membrane ...
Ahmad Rashki, Hosseiali Abdi
doaj  

VIRULENCE FACTORS OF E. COLI, ASSOCIATED WITH URINARY TRACT INFECTIONS

Problems of Infectious and Parasitic Diseases
Urinary tract infections (UTIs) are the most common type of infections second only to respiratory tract infections. Millions of UTI cases are reported each year, affecting in- and outpatients.
Marina Miroshnikova, Denis Niyazi, Temenuga Stoeva   +2 more
doaj   +1 more source