Results 11 to 20 of about 27,958 (218)

Catch-bond mechanism of the bacterial adhesin FimH [PDF]

, 2016
Ligand-receptor interactions that are reinforced by mechanical stress, so-called catch-bonds, play a major role in cell-cell adhesion. They critically contribute to widespread urinary tract infections by pathogenic Escherichia coli strains.
Sauer, Maximilian M., Navarra, Giulio, Bernèche, Simon, Maier, Timm, Eras, Jonathan, Glockshuber, Rudi, Jakob, Roman P., Ernst, Beat, Baday, Sefer, Eris, Deniz   +9 more
core   +1 more source

A two-domain elevator mechanism for sodium/proton antiport [PDF]

, 2013
Sodium/proton (Na+/H+) antiporters, located at the plasma membrane in every cell, are vital for cell homeostasis1. In humans, their dysfunction has been linked to diseases, such as hypertension, heart failure and epilepsy, and they are well-established ...
von Ballmoos, Christoph, Kang, Hae Joo, Povilas Uzdavinys, Newstead, Simon, Beckstein, Oliver, Oliver Beckstein, Simon Newstead, Uzdavinys, Povilas,, Drew, David,, So Iwata, Chiara Lee, Lee, Chiara, Christoph von Ballmoos, Cameron, Alexander, Dotson, David L., Drew, David, Cameron, Alexander D., Iwata, So, Hae Joo Kang, David L. Dotson, Alexander D. Cameron, von Ballmoos, Christoph,, David Drew, Uzdavinys, Povilas   +23 more
core   +1 more source

Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization [PDF]

, 2001
The nuclear lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear membrane. The lamina is proposed to be an important determinant of nuclear structure, but there has been little direct testing of this idea.
Tinglu Guan, Gerace, L, Eric C. Schirmer, Schirmer, Eric, Guan, T, Larry Gerace   +5 more
core   +1 more source

Protein Folding and Macromolecular Dynamics: Fundamental Limits of Length and Time Scales [PDF]

, 2012
In this thesis, physics-based models of protein folding at the secondary and tertiary level are developed to resolve long-standing issues of protein folding kinetics.
Lin, Milo Miaoyu
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The NorM MATE transporter from N. gonorrhoeae: insights into drug and ion Binding from atomistic molecular dynamics simulations

, 2014
The multidrug and toxic compound extrusion transporters extrude a wide variety of substrates out of both mammalian and bacterial cells via the electrochemical gradient of protons and cations across the membrane.
Khalid, Syma, Syma Khalid, Leung, Yuk Ming, Yuk Ming Leung, Holdbrook, Daniel A., Thomas J. Piggot, Piggot, Thomas J., Daniel A. Holdbrook   +7 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

NMR and MD studies of the temperature-dependent dynamics of RNA YNMG-tetraloops

, 2008
In a combined NMR/MD study, the temperature-dependent changes in the conformation of two members of the RNA YNMG-tetraloop motif (cUUCGg and uCACGg) have been investigated at temperatures of 298, 317 and 325 K. The two members have considerable different
Stock, Gerhard, Wöhnert, Jens, Villa, Alessandra, Widjajakusuma, Elisabeth, Schwalbe, Harald (Prof. Dr.), Ferner, Jan, Duchardt-Ferner, Elke   +6 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Development of photocatalysis‐membrane separation reactor systems for aqueous pollutant removal

PhotoMat, EarlyView., 2023
Abstract Background In our rapidly expanding society, the demand for clean water has steadily emerged as one of the most critical issues, promoting the development of numerous water treatment strategies. Aims Coupling photocatalysis and membrane separation technology provides an energy saving and environment‐friendly as well as sustainable method for ...
Junyang Zhang, Yingchun Miao, Yuning Huo, Hexing Li   +3 more
wiley   +1 more source