Results 131 to 140 of about 25,570 (221)

Optimized SPE‐HPLC‐FLD Method for the Simultaneous Determination of Olaparib, Propranolol, and Furosemide in Human Urine

Biomedical Chromatography, Volume 40, Issue 8, August 2026.
ABSTRACT Olaparib belongs to the PARP inhibitors and is widely used as an anticancer drug. Due to frequent side effects, it is usually co‐administered with an antihypertensive, such as propranolol and/or an antidiuretic, such as furosemide. In this study, a highly sensitive HPLC‐FLD method was developed for the simultaneous determination of the three ...
Georgios Kamaris, Antonia Kalagia, Catherine K. Markopoulou   +2 more
wiley   +1 more source

Depression, Suicidality, and Substance Abuse Among Sexual Risk Behavior Subgroups of Male High School Students. [PDF]

Arch Sex Behav
McMahon RC.
europepmc   +1 more source

Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl‐CoA levels, leading to reduced ketogenesis and lipotoxicity, as demonstrated through in vivo and in vitro approaches.
Debora Santos Rocha, Eloisa Vilas‐Boas, Camille C. Caldeira da Silva, Everton L. Vogt, Marcos Yoshinaga, Mariana Pacheco Teixeira de Carvalho, Maiara I. C. Queiroz, Tiago Eugênio Oliveira da Silva, Sayuri Miyamoto, Alicia J. Kowaltowski   +9 more
wiley   +1 more source

Machine learning to predict hospital admission at triage in paediatric emergency care: A meta-analysis. [PDF]

Eur J Pediatr
Pérez BP, Osorio OG, Arias-Colinas M, Moreno JM, Martín-Calvo N.   +4 more
europepmc   +1 more source

2'‐O‐Acetal Levulinic Ester Ribonucleoside 3'‐Phosphoramidites for the Solid‐Phase Synthesis of Long RNA

Current Protocols, Volume 6, Issue 8, August 2026.
Abstract Solid‐phase RNA synthesis is challenging because the 2'‐hydroxyl requires a protecting group that is stable during chain assembly yet easily removable without degrading the product. Driven by the demand for long RNA therapeutics, we report a synthesis method using 2'‐O‐acetal levulinic ester (ALE) ribonucleoside 3'‐O‐phosphoramidites.
Zidi Lyu, Adam Katolik, Masad J. Damha
wiley   +1 more source

Comparative phytochemical, antioxidant, and hemostatic studies of leaf and stem extracts of <i>Rhazya stricta</i> Decne. in human plasma and human peripheral blood mononuclear cells <i>in vitro</i>. [PDF]

Front Mol Biosci
Hamed AI, Mohamed AAA, Ben Aissa MA, Kontek B, Kluska M, Woźniak K, Kowalczyk M, Kowalska I, Oleszek W, Olas B.   +9 more
europepmc   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Photochemical Catalyst-Free Synthesis of Pyrrolidines via a Hofmann-Loffler-Freytag Reaction. [PDF]

Molecules
Shkembi ASJ, Pasqualon L, Serviou SK, Lantzanakis MVG, Kokotos CG.   +4 more
europepmc   +1 more source

Environmental Seismic Intensity Scale 2007 - ESI 2007.

, 2007
MICHETTI, ALESSANDRO MARIA, F. AUDEMARD, T. AZUMA, J. CLAGUE, V. COMERCI, E. ESPOSITO, L. GUERRIERI, A. GRPINAR, J. MCCALPIN, B. MOHAMMADIOUN, N. A. MRNER, Y. OTA, S. PORFIDO, E. ROGHOZIN, L. SERVA, R. TATEVOSSIAN E. VITTORI   +15 more
openaire   +1 more source

Stage‐Specific Metabolic and Proteomic Dynamics Underlying Ripening and Quality Formation in Tropical Evergreen Pomegranate

eFood, Volume 7, Issue 4, August 2026.
Integrated multi‐omics reveals that pomegranate ripening between 90 and 130 days drives optimal sugar‐acid balance and pigmentation via coordinated regulation of phenylpropanoid, flavonoid, and carbohydrate metabolism pathways. ABSTRACT Pomegranate fruit development involves coordinated physiological, metabolic, and proteomic changes shaping coloration
Yawen Zhang, Ling Wei, Kaibing Zhou, Qin Deng, Muhammad Mobeen Tahir, Hongxia Wu, Minjie Qian   +6 more
wiley   +1 more source