Results 91 to 100 of about 111,421 (336)

L-Type Amino Acid Transporter-1 Overexpression and Melphalan Sensitivity in Barrett's Adenocarcinoma

Neoplasia: An International Journal for Oncology Research, 2004
The L-type amino acid transporter-1 (LAT-1) has been associated with tumor growth. Using cDNA microarrays, overexpression of LAT-1 was found in 87.5% (7/8) of esophageal adenocarcinomas relative to 12 Barrett's samples (33% metaplasia and 66% dysplasia ...
Jules Lin, Duna A. Raoof, Dafydd G. Thomas, Joel K. Greenson, Thomas J. Giordano, Gregory S. Robinson, Maureen J. Bourner, Christopher T. Bauer, Mark B. Orringer, David G. Beer   +9 more
doaj   +1 more source

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

Angewandte Chemie International Edition, EarlyView.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Endoscopic screening for esophageal squamous cell carcinoma [PDF]

, 2013
Esophageal cancer (EC) is the eighth common cancer and the sixth most common cause of death from cancer worldwide. Esophageal squamous cell carcinoma (ESCC) remains the most common type of EC in the developing world and an important health problem in ...
Amiriani, T., Khoshnia, M., Merat, S., Nouroozi, A., Pourshams, A., Roshandel, G., Semnani, S.   +6 more
core  

Foregut microbiome in development of esophageal adenocarcinoma [PDF]

, 2010
Esophageal adenocarcinoma (EA), the type of cancer linked to heartburn due to gastroesophageal reflux diseases (GERD), has increased six fold in the past 30 years. This cannot currently be explained by the usual environmental or by host genetic factors.
Aaron Tenney, Carlos W. Nossa, Daniel Brami, Eoin L. Brodie, Erika Gerz, Fritz Francois, Gary L. Andersen, Indresh K. Singh, Karen E. Nelson, Les Foster, Liying Yang, Manolito Torralba, Mathangi Thiagarajan, Mengling Liu, Michael Poles, Monika Bihan, Morris Traube, Navjeet Singh, Pinak Shah, Shibu Yooseph, Stuart M. Brown, Sukhleen Bedi, Tamasha Parsons, Todd Z. DeSantis, William E. Oberdorf, Yu Chen, Yu-Hui Rogers, Zhiheng Pei   +27 more
core   +2 more sources

Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells

BioEssays, EarlyView.
Primary cilia are developmentally essential subcellular signaling compartments. However, many differentiated cells lack primary cilia, and cilia disassembly in these tissue contexts has been largely overlooked. We highlight several pathways for primary cilia loss and examine how changes in ciliation states could contribute to diverse pathologies ...
Carolyn M. Ott, Saikat Mukhopadhyay
wiley   +1 more source

The pathologists’ eyes on foregut: histopathological relations in the experimental and routine diagnostics [PDF]

, 2011
SUMMARY I. The study aimed to investigate the incidence of duodeno-gastroesophageal reflux-induced malignoma formation in a series of duodeno-esophageal anastomosis operations in rats.
Németh István Balázs
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Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zeng, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source

Occurrence of acute oesophageal necrosis (black oesophagus) in a single tertiary centre [PDF]

, 2019
Acute oesophageal necrosis (AON) is a rare condition characterised by the endoscopic finding of diffuse, circumferential, black mucosal pigmentation of the oesophagus, which typically stops at the gastro-oesophageal junction.
Annibale, Bruno, Carabotti, Marilia, Corleto, Vito Domenico, DI GIULIO, Emilio, Esposito, Gianluca, Orlando, Davide, Ruggeri, Maurizio   +6 more
core   +1 more source

Efficacy and safety of glecirasib in solid tumors with KRAS G12C mutation: A pooled analysis of two phase I/II trials

Cancer Communications, EarlyView.
Abstract Background Glecirasib, an inhibitor of Kirsten rat sarcoma viral oncogene homolog glycine‐to‐cysteine substitution at codon 12 (KRAS G12C), has exhibited clinical activity in non‐small‐cell lung cancer (NSCLC) and colorectal cancer (CRC).
Jian Li, Ting Deng, Yanhong Gu, Antonio Calles Blanco, Zhihua Li, Chunmei Bai, Lin Wu, Jing Huang, Xingya Li, Yu Yao, Zhengbo Song, Yongsheng Li, Lian Liu, Ligang Xing, Wenming Wu, Julia Martínez‐Pérez, Ayala Hubert, Jon Zugazagoitia, Jian Zhang, Yongsheng Wang, Yanqiu Zhao, Guilan Wen, Guohao Xia, Diansheng Zhong, Xueqin Chen, Kuirong Jiang, Andrea Wang‐Gillam, Yuli Ding, Sumei Liu, Zhiyue Rao, Xinghu Liu, Lin Shen   +31 more
wiley   +1 more source

EXPRESSION OF ENDOPLASMIC RETICULUM OXIDOREDUCTASES (EROS) AND THEIR ROLE IN THE GI TRACT [PDF]

, 2012
It has been shown that some ER redox enzymes are differentially expressed in stomach and oesophagus tissue. The tissues of the gastrointestinal system, which are subject to external changes of environment during the process of digestion, represent a ...
WATSON, GRAEME
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