Results 151 to 160 of about 111,421 (336)

Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma

open access: yesRevista do Colégio Brasileiro de Cirurgiões
OBJECTIVES: To correlate the expression of p53 protein and VEGF with the prognosis of patients submitted to curative resection to treat esophageal adenocarcinoma. METHODS: Forty-six patients with esophageal adenocarcinoma, submitted to curative resection,
Leandro Totti Cavazzola   +8 more
doaj   +1 more source

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

open access: yesMedicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che   +3 more
wiley   +1 more source

Prevalence and factors associated to the types of esophageal cancer in Arzobispo Loayza National Hospital during 2009 to 2013

open access: yesHorizonte Médico, 2015
Objective: To determine the prevalence and the risk factors associated with the different types of esophageal cancer in Arzobispo Loayza National Hospital during 2009-2013. Materials and methods: This study was a retrospective cohort study.
Luis Andrés Norabuena Huapaya
doaj  

Rad51 at the Crossroads: Bridging DNA Repair, Tumorigenesis, and Immune Regulation

open access: yesMed Research, EarlyView.
Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy); (2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 inhibitors, CRISPR/Cas9); and (4) combination approaches (immunotherapy). The figure is created with BioRender.com.
Zhendong Qin   +4 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi   +2 more
wiley   +1 more source

Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

open access: yes, 2013
AIM: To assess tumour regression grade (TRG) and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS: Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal ...
Bailey, Ian   +10 more
core   +1 more source

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