Results 151 to 160 of about 4,777,622 (429)

Cost‐Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers

Advanced Science, EarlyView.
Early detection of hepatocellular carcinoma in patients with liver cirrhosis and/or hepatitis virus B/C infection improves survival. Through marker discovery, 8 methylated DNA markers are identified and a logistic regression model (COMET‐LR) is built in the training set, which achieved 90.0% sensitivity at 97.4% specificity in the validation set.
Tian Yang, Mingda Wang, Nanya Wang, Mingxin Pan, Yu Xu, Qiancheng You, Lanqing Yao, Jiahao Xu, Lihui Gu, Xiaodong Sun, Lei Zhang, Jiayue Xu, Bingsi Li, Guoqiang Wang, Shangli Cai, Guoyue Lv, Feng Shen   +16 more
wiley   +1 more source

Role of photodynamic therapy in the treatment of esophageal cancer

Digestive Endoscopy, 2019
Photodynamic therapy (PDT), a treatment of choice for cancer, induces a photochemical reaction, thereby eradicating tumor cells. This is achieved through the administration of a photosensitizer drug, which is activated with a laser after localization to ...
Hao Wu, T. Minamide, T. Yano
semanticscholar   +1 more source

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Advanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang   +10 more
wiley   +1 more source

Niclosamide, an antihelmintic drug, enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer

Journal for ImmunoTherapy of Cancer, 2019
Background PD-1/PD-L1 blockade has received approval for clinical application due to its encouraging benefit with improving prognosis in selected populations. Unfortunately, the response to immunotherapy for many patients remains unsatisfactory.
Fan Luo, Min Luo, Qi-Xiang Rong, Hong Zhang, Zhen Chen, Fang Wang, Hong-Yun Zhao, Li-Wu Fu   +7 more
doaj   +1 more source

Interactive Radiotherapy Target Delineation with 3D-Fused Context Propagation [PDF]

arXiv, 2020
Gross tumor volume (GTV) delineation on tomography medical imaging is crucial for radiotherapy planning and cancer diagnosis. Convolutional neural networks (CNNs) has been predominated on automatic 3D medical segmentation tasks, including contouring the radiotherapy target given 3D CT volume.
arxiv  

Esophageal Cancer: Esophageal Cancer Drug Therapy

Annals of Oncology, 2012
ABSTRACT For resectable esophageal cancer (stage II/II, non-T4), two courses of pre-operative chemotherapy with 5-fluorouracil (5-FU) plus cisplatin (CDDP) (FP) showed a significant survival benefit compared with post-operative chemotherapy with the same regimen in JCOG9907 trial (5-year survival rate; 60% versus 38%).
openaire   +2 more sources

Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo. [PDF]

, 2015
BACKGROUND: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency.
Alder, Hansjuerg, Chen, Hongping, Croce, Carlo M., Di Leva, Gianpiero, Fadda, Paolo, Farber, John L., Fong, Louise, Garofalo, Michela, Jiang, Yubao, Middleton, Justin, Naidu, Srivatsava, Selmi, Tommaso, Smalley, Karl J., Taccioli, Cristian, Tagliazucchi, Guidantonio Malagoli   +14 more
core   +1 more source

Assessment of body composition and sarcopenia in patients with esophageal cancer: a systematic review and meta-analysis.

Diseases of the esophagus, 2018
There has recently been increased interest in the assessment of body composition in patients with esophageal cancer for the purpose of nutritional evaluation and prognostication.
P. Boshier, Rachel E. Heneghan, S. Markar, Vickie E. Baracos, Donald E. Low   +4 more
semanticscholar   +1 more source

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

Surgical treatment combined with preoperative concentrated irradiation for esophageal cancer [PDF]

, 1967
K Nakayama, Hideo Orihata, Keizo Yamaguchi   +2 more
openalex   +1 more source