Results 291 to 300 of about 297,465 (360)

Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m6A‐YTHDF2‐dependent mechanism

open access: yesiMeta, EarlyView.
Homoharringtonine (HHT), a clinically approved anti‐leukemic drug, directly binds the RNA‐binding protein EWSR1. HHT induces an allosteric conformational switch in the RNA recognition motif of EWSR1, driving self‐association and liquid–liquid phase separation (LLPS). The resulting condensates act as regulatory hubs that sequester the m6A reader YTHDF2,
Ting‐Ting Liu   +17 more
wiley   +1 more source

Correction: NIR-responsive Cu2−xSe@Fc nanoparticles for photothermal- ferroptosis combination therapy in esophageal cancer

open access: yesJournal of Nanobiotechnology
Linlin Shi   +11 more
doaj   +1 more source

Current landscape of immunotherapy in esophageal cancer: a literature review

open access: diamond
Mohamad M Moughnyeh   +3 more
openalex   +1 more source

Fertility and Early Embryonic Development Toxicity of hzVSF‐v13 in Sprague–Dawley Rats

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Humanized virus suppressing factor–variant 13 (hzVSF‐v13), a monoclonal IgG4 antibody, is a potential therapeutic candidate for COVID‐19. Although fertility and embryonic developmental toxicity studies are crucial for the safety evaluation of new drugs, the toxicological profile of hzVSF‐v13 remains unexplored.
Ji‐Seong Jeong   +10 more
wiley   +1 more source

Automatic segmentation of esophageal cancer, metastatic lymph nodes and their adjacent structures in CTA images based on the UperNet Swin network

open access: gold
Runyuan Wang   +10 more
openalex   +1 more source

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