This study identified LAMC2+ epithelial cells through single‐cell sequencing and found that high expression of LAMC2 is associated with the malignant progression of bladder cancer. HdWGCNA and transcriptome sequencing revealed the SerpinB3/STAT3/CD44 axis. Diosmetin was selected as a potential LAMC2 inhibitor.
Yutong Chen +17 more
wiley +1 more source
Comparison of the efficacy of different treatments after non-curative endoscopic resection of superficial esophageal carcinoma: a meta-analysis. [PDF]
Wang R, Peng LJ, Tian SN.
europepmc +1 more source
Proportion of Screen‐Detected Gastrointestinal Cancers From the National Cancer Registry in Japan
Using the data from the Japanese National Cancer Registry, screen‐detected gastrointestinal cancers accounted for roughly 20% of all detected routes. We also found that the proportion of screen‐detected cancers was positively correlated with screening participation rates, supporting screen‐detected cancer proportion as a valuable indicator for ...
Ryuji Okamoto +6 more
wiley +1 more source
Erratum: [Corrigendum] TERT promoter regulating melittin expression induces apoptosis and G<sub>0</sub>/G<sub>1</sub> cell cycle arrest in esophageal carcinoma cells. [PDF]
Zhou C +11 more
europepmc +1 more source
TRIM59 Drives Bladder Cancer Progression Through E3 Ligase‐Dependent K48‐Linked Degradation of PTRF
Schematic model of TRIM59‐driven BLCA progression through K48‐linked ubiquitination and proteasomal degradation of PTRF, leading to AKT activation and c‐Myc upregulation. ABSTRACT Tripartite motif‐containing 59 (TRIM59) is an E3 ubiquitin ligase implicated in multiple malignancies, but its role in bladder cancer (BLCA) remains incompletely understood ...
Junlin Gan +9 more
wiley +1 more source
A Rare Pulmonary Complication of Esophageal Carcinoma: A Case of an Acquired Esophago-Pulmonary Fistula. [PDF]
Jesica S +3 more
europepmc +1 more source
Compared with PT‐CAFs, LN‐CAFs exhibited a myofibroblast‐like phenotype, enhanced tumor stemness‐promoting activity, and fibrosis‐, EMT‐, and hypoxia‐related transcriptomic signatures. LN‐CAF‐related gene signatures were independently associated with poor prognosis in head and neck squamous cell carcinoma.
Hiroyuki Hagiwara +8 more
wiley +1 more source
ZIP8 modulates ferroptosis to drive esophageal carcinoma progression. [PDF]
Yang Z +15 more
europepmc +1 more source
WDR12 Promotes Glucose Metabolism via PFKFB4 Upregulation in Gastric Cancer
WDR12 promotes glucose metabolism and tumor growth in GC. Mechanistically, WDR12 interacts with TDP43 and appears to enhance PFKFB4 expression, thereby promoting glucose metabolism. ABSTRACT Metabolic reprogramming is a hallmark of gastric cancer (GC); however, the role of transcriptional regulators in modulating glycolysis remains incompletely ...
Rutong Zhang +5 more
wiley +1 more source
Corrigendum to: Magnolol promotes the autophagy of esophageal carcinoma cells by upregulating HACE1 gene expression. [PDF]
Huang K, Zhang B, Feng Y, Ma H.
europepmc +1 more source

