Results 231 to 240 of about 785,637 (307)

LAMC2+ Epithelial Cells Drive Bladder Cancer Progression and Predict Immunotherapy Response via SERPINB3/STAT3/CD44 Axis

open access: yesCancer Science, EarlyView.
This study identified LAMC2+ epithelial cells through single‐cell sequencing and found that high expression of LAMC2 is associated with the malignant progression of bladder cancer. HdWGCNA and transcriptome sequencing revealed the SerpinB3/STAT3/CD44 axis. Diosmetin was selected as a potential LAMC2 inhibitor.
Yutong Chen   +17 more
wiley   +1 more source

Proportion of Screen‐Detected Gastrointestinal Cancers From the National Cancer Registry in Japan

open access: yesCancer Science, EarlyView.
Using the data from the Japanese National Cancer Registry, screen‐detected gastrointestinal cancers accounted for roughly 20% of all detected routes. We also found that the proportion of screen‐detected cancers was positively correlated with screening participation rates, supporting screen‐detected cancer proportion as a valuable indicator for ...
Ryuji Okamoto   +6 more
wiley   +1 more source

TRIM59 Drives Bladder Cancer Progression Through E3 Ligase‐Dependent K48‐Linked Degradation of PTRF

open access: yesCancer Science, EarlyView.
Schematic model of TRIM59‐driven BLCA progression through K48‐linked ubiquitination and proteasomal degradation of PTRF, leading to AKT activation and c‐Myc upregulation. ABSTRACT Tripartite motif‐containing 59 (TRIM59) is an E3 ubiquitin ligase implicated in multiple malignancies, but its role in bladder cancer (BLCA) remains incompletely understood ...
Junlin Gan   +9 more
wiley   +1 more source

Myofibroblast‐Like CAFs in Metastatic Lymph Nodes Drive Tumor Stemness and Poor Prognosis in Head and Neck Cancer

open access: yesCancer Science, EarlyView.
Compared with PT‐CAFs, LN‐CAFs exhibited a myofibroblast‐like phenotype, enhanced tumor stemness‐promoting activity, and fibrosis‐, EMT‐, and hypoxia‐related transcriptomic signatures. LN‐CAF‐related gene signatures were independently associated with poor prognosis in head and neck squamous cell carcinoma.
Hiroyuki Hagiwara   +8 more
wiley   +1 more source

ZIP8 modulates ferroptosis to drive esophageal carcinoma progression. [PDF]

open access: yesCell Death Dis
Yang Z   +15 more
europepmc   +1 more source

WDR12 Promotes Glucose Metabolism via PFKFB4 Upregulation in Gastric Cancer

open access: yesCancer Science, EarlyView.
WDR12 promotes glucose metabolism and tumor growth in GC. Mechanistically, WDR12 interacts with TDP43 and appears to enhance PFKFB4 expression, thereby promoting glucose metabolism. ABSTRACT Metabolic reprogramming is a hallmark of gastric cancer (GC); however, the role of transcriptional regulators in modulating glycolysis remains incompletely ...
Rutong Zhang   +5 more
wiley   +1 more source

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