Results 191 to 200 of about 152,309 (255)
Limited association between HRR gene alterations and HRD in molecular tumor board cancer samples: Who should be tested for HRD?
International Journal of Cancer, EarlyView.What's New?
Currently, no published data on homologous recombination deficiency (HRD) testing in the setting of molecular tumor boards exist. This study in a cohort of 237 patients encompassing 24 different tumor entities assessed by a molecular tumor board shows that inactivating alterations of BRCA1/2 are not always associated with an elevated ...Christoph Schubart, Lars Tögel, Maria Giulia Carta, Philip Hetzner, Lina Helbig, Charlotte Zaglas, Maria Ziegler, Robert Stöhr, Annett Hölsken, Juliane Hoyer, Fulvia Ferrazzi, Clemens Neufert, Sebastian Lettmaier, Marianne Pavel, Henriette Golcher, Sarina K. Mueller, Florian Fuchs, Carla E. Schulmeyer, Matthias W. Beckmann, Bernd Wullich, Abbas Agaimy, Andre Reis, Arndt Hartmann, Norbert Meidenbauer, Silvia Spoerl, Florian Haller, Evgeny A. Moskalev +26 morewiley +1 more sourceTranscriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration
International Journal of Cancer, EarlyView.What's New?
SOX2 is one of the key developmental genes with a reported altered expression in many tumors. The mechanisms underlying SOX2 regulation in cancer, however, remain elusive. This study shows that TP53 transcriptionally regulates SOX2 through binding to its promoter and the SRR2 enhancer.Patricia Lado‐Fernández, Jéssica M. Vilas, Tânia Fernandes, Carmen Carneiro, Sabela Da Silva‐Álvarez, Valentín Estévez‐Souto, Pablo Pedrosa, Miguel González‐Barcia, Luis E. Abatti, Jennifer A. Mitchell, Carmen Rivas, Gema Moreno‐Bueno, Anxo Vidal, Manuel Collado +13 morewiley +1 more sourceHospital variation in treatment for synchronous metastatic esophageal and gastric cancer: A nationwide population‐based study in the Netherlands
International Journal of Cancer, EarlyView.What's New?
A range of treatment options exist for metastatic esophageal (EC) and gastric cancer (GC). Which modalities or combination thereof are optimal for these malignancies, however, remains uncertain. Here, the authors examined differences in systemic treatment for metastatic EC and GC across hospitals in the Netherlands.Julie F. M. Geerts, Pauline A. J. Vissers, Bianca Mostert, Bas P. L. Wijnhoven, Brigitte C. M. Haberkorn, Marie‐Paule G. F. Anten, Camiel Rosman, Geert‐Jan Creemers, Harm Westdorp, Maurice J. C. van der Sangen, Rob H. A. Verhoeven, Grard A. P. Nieuwenhuijzen +11 morewiley +1 more sourceCancer incidence in people with HIV in Italy: Comparison of the ICONA COHORT with general population data
International Journal of Cancer, EarlyView.What's New?
Immune suppression induced by HIV infection significantly increases the risk of certain cancers among people with HIV (PWH). In the present study, the authors investigated cancer incidence among HIV‐infected individuals in Italy using data from the Italian Cohort Naïve Antiretrovirals. Comparison with the corresponding general population in Pierluca Piselli, Alessandro Tavelli, Claudia Cimaglia, Camilla Muccini, Alessandra Bandera, Giulia C. Marchetti, Carlo Torti, Valentina Mazzotta, Luca Pipitò, Alessandro Caioli, Enrico Girardi, Andrea Antinori, Diego Serraino, Antonella d'Arminio Monforte, Antonella Cingolani, Icona Foundation Study Group, A d'Arminio Monforte, A Antinori, S Antinori, A Castagna, R Cauda, G Di Perri, E Girardi, R Iardino, A Lazzarin, GC Marchetti, C Mussini, E Quiros‐Roldan, L Sarmati, B Suligoi, F von Schloesser, P Viale, A d'Arminio Monforte, A Antinori, A Castagna, F Ceccherini‐Silberstein, A Cingolani, A Cozzi‐Lepri, A Di Biagio, E Girardi, A Gori, S Lo Caputo, G Marchetti, F Maggiolo, C Mussini, M Puoti, CF Perno, C Torti, A Antinori, A Bandera, S Bonora, A Calcagno, D Canetti, A Castagna, F Ceccherini‐Silberstein, A Cervo, A Cingolani, P Cinque, A Cozzi‐Lepri, A d'Arminio Monforte, A Di Biagio, R Gagliardini, A Giacomelli, E Girardi, N Gianotti, A Gori, G Guaraldi, S Lanini, G Lapadula, M Lichtner, A Lai, S Lo Caputo, G Madeddu, F Maggiolo, V Malagnino, G Marchetti, A Mondi, V Mazzotta, C Mussini, S Nozza, CF Perno, S Piconi, C Pinnetti, M Puoti, E Quiros Roldan, R Rossotti, S Rusconi, MM Santoro, A Saracino, L Sarmati, V Spagnuolo, N Squillace, V Svicher, L Taramasso, C Torti, A Vergori, A Cozzi‐Lepri, S De Benedittis, I Fanti, M Giotta, C Marelli, A Rodano, A Tavelli, M Cernuschi, L Cosmaro, A Perziano, V Calvino, D Russo, M Farinella, N Policek, VL Del Negro, M Augello, S Carrara, S Graziano, G Prota, S Truffa, D Vincenti, R Rovito, M Sgarlata, Italy A Giacometti, A Costantini, V Barocci, A Saracino, C Santoro, E Milano, L Comi, C Suardi, P Viale, L Badia, S Cretella, EM Erne, A Pieri, E Quiros Roldan, E Focà, B Menzaghi, C Abeli, L Chessa, F Pes, P Maggi, L Alessio, G Nunnari, BM Celesia, J Vecchiet, K Falasca, A Pan, S Dal Zoppo, D Segala, F Bartalesi, A Bartoloni, B Borchi, C Costa, S Lo Caputo, S Ferrara, M Bassetti, E Pontali, S Blanchi, N Bobbio, C. Del Borgo, R. Marocco, G. Mancarella, S Piconi, C Molteni, S Rusconi, G Canavesi, G Pellicanò, G Marchetti, S Antinori, A Gori, M Puoti, A Castagna, A Bandera, V Bono, MV Cossu, A Giacomelli, R Lolatto, MC Moioli, L Pezzati, S Diotallevi, C Tincati, C Mussini, M Menozzi, P Bonfanti, G Lapadula, V Sangiovanni, I Gentile, V Esposito, N Coppola, FM Fusco, G Di Filippo, V Rizzo, N Sangiovanni, S Martini, AM Cattelan, D Leoni, A Cascio, M Trizzino, D Francisci, E Schiaroli, G Parruti, F Sozio, D Messeri, SI Bonelli, C Lazzaretti, R Corsini, A Antinori, R Cauda, C Mastroianni, L Sarmati, A Latini, A Cingolani, I Mastrorosa, S Lamonica, M Capozzi, M Camici, I Mezzaroma, M Rivano Capparuccia, G Iaiani, C Stingone, L Gianserra, J Paulicelli, MM Plazzi, G d'Ettore, M Fusto, M Lichtner, I Coledan, G Madeddu, A De Vito, M Fabbiani, F Montagnani, A Franco, R Fontana Del Vecchio, D Francisci, C Di Giuli, GC Orofino, G Calleri, G Di Perri, S Bonora, G Accardo, C Tascini, A Londero, G Battagin, S Nicolè, G Starnini, S Dell'Isola +243 morewiley +1 more sourceSingle‐cell sequencing reveals the role of IL‐33+ endothelial subsets in promoting early gastric cancer progression
iMeta, EarlyView.A single‐cell atlas was established to reveal the molecular characteristics of early gastric cancer (EGC). In combination with organoids, animal models, and clinical samples, it was found that subpopulations such as pit mucous‐like cell (PMC‐like), proliferating cell (PC), CH25H+ CD4+ T cell, IL‐33+ endothelial cell, and ADAMTSL2+ endothelial cell are ...Li Zhou, Mei Yang, Chao Deng, Manqiu Hu, Suhua Wu, Kewen Lai, Lili Zhang, Zhiji Chen, Qin Tang, Qingliang Wang, Lu Chen, Runmin Zha, Yuanyuan Chen, Yibo Tan, Song He, Zhihang Zhou +15 morewiley +1 more source
