Results 21 to 30 of about 53,512 (172)

The Diminution of R‐Loops Generated by LncRNA DSP‐AS1 Inhibits DSP Gene Transcription to Impede the Re‐Epithelialization During Diabetic Wound Healing

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Down‐regulated LncRNA DSP‐AS1, the diminution of R‐loop formation, reduced Ten‐eleven translocation 3 (TET3) occupancy, inhibited DNA demethylation at the DSP promoter, and disrupted re‐epithelialization process proceed sequentially during delayed diabetic wound healing.
Chen Yang, Hong Lian, Hengli Luo, Chenlin Song, Jianghong Lin, Zhuoxian Liang, Yulin Yang, Xiaosi Hong, Shaohua Li, Yanbo Chen, Liangyan Wu, Li Yan, Sifan Chen, Meng Ren   +13 more
wiley   +1 more source

Self-transport of swimming bacteria is impaired by porous microstructure [PDF]

arXiv, 2022
Motility is a fundamental survival strategy of bacteria to navigate porous environments. Swimming cells thrive in quiescent wetlands and sediments at the bottom of the marine water column, where they mediate many essential biogeochemical processes.
arxiv  

Massage‐Mimicking Nanosheets Mechanically Reorganize Inter‐organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease

Advanced Science, EarlyView.
Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li, Liwen Huang, Chenxiao Guo, Jing Ren, Xi Chen, Yachu Ke, Zengyu Xun, Wenzhuo Hu, Yilin Qi, Heping Wang, Zhongying Gong, Xing‐Jie Liang, Xue Xue   +12 more
wiley   +1 more source

Enhanced persistence and collective migration in cooperatively aligning cell clusters [PDF]

, 2020
Most cells possess the capacity to locomote. Alone or collectively, this allows them to adapt, to rearrange, and to explore their surroundings. The biophysical characterization of such motile processes, in health and disease, has so far focused mostly on two limiting cases: single-cell motility on the one hand, and the dynamics of confluent tissues ...
arxiv   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Rapid and Noninvasive Early Detection of Lung Cancer by Integration of Machine Learning and Salivary Metabolic Fingerprints Using MS LOC Platform: A Large‐Scale Multicenter Study

Advanced Science, EarlyView.
Salivary metabolic signatures associated with lung cancer are systematically characterized through a self‐developed high‐throughput mass spectrometry Lab‐on‐a‐Chip platform. Utilizing these metabolic fingerprints, SalivaMLD, an integrated machine‐learning‐driven classification model is developed and demonstrates superior performance in detecting lung ...
Shuang Lin, Runlan Yan, Junqi Zhu, Bei Li, Yinyan Zhong, Shuang Han, Huiting Wang, Jianmin Wu, Zhao Chen, Yuyue Jiang, Aiwu Pan, Xuqing Huang, Xiaoming Chen, Pingya Zhu, Sheng Cao, Wenhua Liang, Peng Ye, Yue Gao   +17 more
wiley   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Accurate and Noninvasive Dysphagia Assessment via a Soft High‐Density sEMG Electrode Array Conformal to the Submental and Infrahyoid Muscles

Advanced Science, EarlyView.
A stretchable, breathable, large‐area high‐density sEMG (HD‐sEMG) electrode array is reported, which enables seamless integration to the complex surface of the submental and infrahyoid muscles to detect high‐fidelity HD‐sEMG signals during swallowing.
Weijie Hong, Lin Mao, Kai Lin, Chongyuan Huang, Yanyan Su, Shun Zhang, Chengjun Wang, Daming Wang, Jizhou Song, Zuobing Chen   +9 more
wiley   +1 more source

Effect of Intraoperative Posture on Accurate Diagnostic Rate of Intraoperative Nerve Monitoring During Esophagectomy

Annals of Gastroenterological Surgery, EarlyView.
Adequate contact between the intubation tube and the vocal cord muscles is crucial for effective intraoperative nerve monitoring use during esophagectomy. Additionally, intraoperative posture significantly affects diagnostic outcomes and should be carefully considered.
Masami Yuda, Keita Takahashi, Yoshitaka Ishikawa, Takanori Kurogochi, Akira Matsumoto, Naoko Fukushima, Takahiro Masuda, Naoto Takahashi, Fumiaki Yano, Ken Eto   +9 more
wiley   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source