Rethinking Matrigel: The Complex Journey to Matrix Alternatives in Organoid Culture
Advanced Science, EarlyView.Matrigel remains the most widely used scaffold in organoid and 3D culture despite its murine origin, variability, and translational limitations. This review discusses the barriers to replacing Matrigel with xeno‐free alternatives and introduces practical tools, including a matrix selection checklist and scaffold assessment criteria, to guide the ...
Lisa Wolff, Sven Hendrix
wiley +1 more source
A Case of Esophageal Intramural Pseudodiverticulosis
Gut and Liver, 2011 Esophageal intramural pseudodiverticulosis (EIP) is a rare benign disease that is characterized by multiple tiny flaskshaped outpouching lesions of the esophageal wall. The etiology is unknown, but the pathologic fi ndings include dilatation of excretory
doaj +1 more source
Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity
Advanced Science, EarlyView.Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang +25 more
wiley +1 more source
What is the quality of smoking cessation advice in guidelines of tobacco-related diseases? [PDF]
, 2015 Smoking is a major risk factor for a range of diseases, and quitting smoking provides considerable benefits to health. It therefore follows that clinical guidelines on disease management, particularly for diseases caused by smoking, should include ...
Agrawal, Sanjay +5 more
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Outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms in patients with liver cirrhosis. [PDF]
Clin Endosc, 2022 Choi YK +10 more
europepmc +1 more source
Advanced Science, EarlyView.This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan +7 more
wiley +1 more source
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
Advanced Science, EarlyView.This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha +11 more
wiley +1 more source
Sa1963 CLUTCH CUTTER IS A SAFE DEVICE FOR PERFORMING ENDOSCOPIC SUBMUCOSAL DISSECTION OF SUPERFICIAL ESOPHAGEAL NEOPLASM: A WESTERN EXPERIENCE [PDF]
, 2018 Tarek Sawas +5 more
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Advanced Science, EarlyView.Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian +11 more
wiley +1 more source
Preoperative Diagnosis of an Esophageal Duplication Cyst by Endoscopic Ultrasound Examination
DiagnosticsA 78-year-old woman was referred to our hospital for close examination of an extramural submucosal tumor in the gastroesophageal region, suspected based on an imaging test performed for a chief complaint of epicardial pain while eating. Contrast-enhanced
Akane Shimakura +3 more
doaj +1 more source