Results 131 to 140 of about 78,845 (337)

Application of a self-assembling peptide matrix prevents esophageal stricture after circumferential endoscopic submucosal dissection in a pig model.

open access: yesPLoS ONE, 2019
IntroductionCircumferential endoscopic submucosal dissection (ESD) allows to treat large esophageal superficial neoplasms, however with a high occurrence of severe esophageal strictures.
Sarra Oumrani   +8 more
doaj   +1 more source

Application of regenerative medical technology using tissue‐engineered cell sheets for endoscopic submucosal dissection of esophageal neoplasms [PDF]

open access: bronze, 2014
Takeshi Ohki   +7 more
openalex   +1 more source

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

open access: yesAdvanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He   +15 more
wiley   +1 more source

Endoscopic Resection for Synchronous Esophageal Squamous Cell Carcinoma and Gastric Adenocarcinoma in Early Stage Is a Possible Alternative to Surgery

open access: yesGut and Liver, 2015
Background/AimsWe investigated the clinical outcomes according to the method of treatment in synchronous esophageal and gastric cancer.Methods : Synchronous esophageal squamous cell carcinoma and gastric adenocarcinoma were diagnosed in 79 patients ...
doaj   +1 more source

LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5

open access: yesAdvanced Science, EarlyView.
Li et al. innovatively map the kinase‐substrate network in esophageal cancer metastasis. Their study demonstrates that LIM domain kinase 1 (LIMK1) and Cyclin‐dependent kinase 5 (CDK5) synergistically increase the phosphorylation of β‐catenin, thereby activating the Wnt/β‐catenin signaling pathway to promote esophageal cancer metastasis.
Shu‐Jun Li   +27 more
wiley   +1 more source

Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy

open access: yesAdvanced Science, EarlyView.
This study employs neutrophils for the precise delivery of anti‐CD47 antibodies, combined with bacterial outer membrane vesicles, to enhance macrophage phagocytic function in the tumor microenvironment. This approach effectively activates T‐cell anti‐tumor immune responses and significantly reduces the risk of postoperative tumor recurrence and ...
Meng Guan   +15 more
wiley   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang   +13 more
wiley   +1 more source

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