Results 111 to 120 of about 60,843 (278)

Transcriptomic signatures and network‐based methods uncover new senescent cell anti‐apoptotic pathways and senolytics

open access: yesThe FEBS Journal, Volume 292, Issue 8, Page 1950-1971, April 2025.
This study identifies new senescent cell antiapoptotic pathways (SCAPs) by analyzing transcriptomic signatures and co‐expression networks. We uncover novel antiapoptotic pathways, called SCAPs, and propose potential senolytic drugs, including Fluorouracil, which targets key SCAPs.
Samael Olascoaga   +6 more
wiley   +1 more source

Morphological features of serosa‐associated lymphoid clusters of the rat parietal pleura: Exploring a relatively unexplored system

open access: yesJournal of Anatomy, EarlyView.
This study explored serosa‐associated lymphoid clusters in rat pleura (pSALCs), identifying their distribution and categorizing them into four morphological types. Data provided by this study form the basis for future morphological comparisons with humans and the potential to extrapolate functional characteristics of pSALCs from experimental studies in
Rosa E. Lagerwerf   +4 more
wiley   +1 more source

The Milan Score Predicts Objective Gastroesophageal Reflux Disease in Patients With Type 2 Esophagogastric Junction

open access: yesNeurogastroenterology &Motility, EarlyView.
The novel manometric parameter Milan Score could be useful in predicting which patients with type 2 EGJ have a high likelihood of objective GERD, therefore discriminating which patients may need escalation of GERD investigation and management. ABSTRACT Introduction High‐resolution manometry (HRM) allows assessment of esophagogastric junction (EGJ ...
Davide Ferrari   +29 more
wiley   +1 more source

Expanding Training Data for Endoscopic Phenotyping of Eosinophilic Esophagitis [PDF]

open access: yesarXiv
Eosinophilic esophagitis (EoE) is a chronic esophageal disorder marked by eosinophil-dominated inflammation. Diagnosing EoE usually involves endoscopic inspection of the esophageal mucosa and obtaining esophageal biopsies for histologic confirmation.
arxiv  

The Milan Score is an Effective Manometric Tool to Predict Gastroesophageal Reflux in Patients With Laryngopharyngeal Symptoms

open access: yesNeurogastroenterology &Motility, EarlyView.
Patients with isolated LPS demonstrated a lower likelihood of EGJ disruption, pathologic GERD, and abnormal Milan score. The Milan score performed similarly well in the identification of GERD in both LPS and typical symptoms. The Milan score could therefore be used as an upfront test in LPS patients.
Stefano Siboni   +26 more
wiley   +1 more source

Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russian Society for the Prevention of Noncommunicable Diseases, Scientific Community for Human Microbiome Research)

open access: yesРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim. These recommendations are developed for practitioners in order to familiarize them with modern diagnostic methods, management features and pharmacotherapy of patients with gastroesophageal reflux disease (GERD).General provisions.
V. T. Ivashkin   +28 more
doaj   +1 more source

Prevalence and Factors Associated With Symptom Profiles of Disorders of Gut‐Brain Interaction in Obesity Before and After Treatment

open access: yesNeurogastroenterology &Motility, EarlyView.
DGBI symptoms are common in obesity and have the potential to exacerbate negative health outcomes. In general, the prevalence of DGBI symptoms decreases after obesity treatment, but patients can also shift from one GI symptom profile to another. ABSTRACT Background & Aims Disorders of gut‐brain interaction (DGBI) in obesity could impair health outcomes.
Esther Colomier   +11 more
wiley   +1 more source

Additional Diagnostic Yield of Ambulatory 24‐h High Resolution Manometry With Impedance in Patients With Non‐Cardiac Chest Pain or Non‐Obstructive Dysphagia

open access: yesNeurogastroenterology &Motility, EarlyView.
Spastic and hypercontractile esophageal motor disorders can cause retrosternal pain and/or dysphagia but may be missed by short‐term high resolution manometry (HRM). 24‐h‐HRM detected considerable circadian variability of esophageal contractility and markedly increased the percentage of patients diagnosed with a major motor disorder.
Jutta Keller   +6 more
wiley   +1 more source

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