Results 121 to 130 of about 132,043 (333)

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, EarlyView.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

ASGE Technology Status Evaluation Report: wireless esophageal pH monitoring system [PDF]

, 2005
Poonputt Chotiprashidi, Julia Liu, Steven Carpenter, Ram Chuttani, James DiSario, Nadeem Hussain, Lehel Somogyi, Bret T. Petersen   +7 more
openalex   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Long-term follow-up results of endoscopic treatment of gastroesophageal reflux disease with the MUSE TM endoscopic stapling device [PDF]

, 2015
Background The initial 6-month data for MUSE™ (Medigus, Omer, Israel) endoscopic stapling device were reported (Zacherl et al. in Surg Endosc 29:220–229, 2015).
Bapaye, Amol, Bonavina, Luigi, Kessler, William R., Kim, Hong Joo, Kwon, Chang-Il, Lehman, Glen A., McNulty, Gail, Selzer, Don J.   +7 more
core   +3 more sources

Multifrequency Multiparameter Magnetic Resonance Elastography Applied to an In Vivo Porcine Model for Assessing Portal Hypertension

Portal Hypertension &Cirrhosis, EarlyView.
Portal hypertension, a critical complication in chronic liver disease, has long relied on invasive hepatic venous pressure gradient measurement for definitive diagnosis. This study establishes that multifrequency three‐dimensional magnetic resonance elastography (3D‐MRE) can noninvasively quantify portal pressure, with splenic stiffness and loss ...
Bai Du, Xiaolong Qi, Yujia Ma, Chen Pan, Qijun Wu, Meng Niu, Yu Shi   +6 more
wiley   +1 more source

Assessment of Esophageal Motility Disorders in Patients with Refractory Gastroesophageal Reflux Disease

Acta Medica Iranica, 2022
There is insufficient data about esophageal body dysmotility in patients with refractory gastroesophageal reflux disease (RGERD) who have inadequate response to proton pump inhibitors (PPIs) treatment.
Asghar Bagherzadeh, Saeed Abdi, Mohammad Reza Zali, Shooka Mohammadi   +3 more
doaj  

Day-to-day discrepancy in Bravo pH monitoring is related to the degree of deterioration of the lower esophageal sphincter and severity of reflux disease [PDF]

, 2011
Shahin Ayazi, Jeffrey A. Hagen, Joerg Zehetner, Farzaneh Banki, Florian Augustin, Ali Ayazi, Steven R. DeMeester, Daniel Oh, Helen J. Sohn, John C. Lipham, Tom R. DeMeester   +10 more
openalex   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Predomínio de manifestações respiratórias na indicação de pHmetria esofágica prolongada em crianças Predominant respiratory symptoms in indications for prolonged esophageal pH-monitoring in children

Arquivos de Gastroenterologia, 2005
RACIONAL: Observa-se um aumento na prevalência de complicações extra-esofágicas do refluxo gastroesofágico. A avaliação do perfil de pacientes submetidos a pHmetria esofágica prolongada poderia auxiliar na identificação de pacientes que poderiam se ...
Helena Ayako Sueno Goldani, Themis Reverbel da Silveira, Renata Rocha, Luciana Celia, Lucas Dalle Molle, Sergio Gabriel Silva de Barros   +5 more
doaj   +1 more source

Normal values of 24-hour ambulatory esophageal impedance-pH monitoring in a rural South African cohort of healthy participants [PDF]

, 2015
Eugene Jamot Ndebia, Alastair M. Sammon, E. Umapathy, Jehu Iputo   +3 more
openalex   +1 more source