Results 71 to 80 of about 34,431 (291)

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Russian Consensus: Standardization of Indications for Surgical Treatment of GERD

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim: to present the results of an Expert Consensus on standardization of indications for surgical treatment of gastroesophageal reflux disease (GERD). Materials and methods. The issues of standardization of indications for surgical treatment of GERD were
I. Ye. Khatkov, D. S. Bordin, O. S. Vasnev, S. R. Abdulkhakov, A. S. Allakhverdyan, D. N. Andreev, V. V. Anishchenko, I. G. Bakulin, N. V. Bakulina, M. V. Burmistrov, E. R. Valitova, D. I. Vasilevsky, F. P. Vetshev, E. A. Gallyamov, S. A. Domrachev, R. Ye. Izrailov, V. A. Isakov, V. O. Kaybysheva, M. A. Koshkin, Yu. A. Kucheryavyy, M. A. Livzan, O. E. Lutsevich, I. V. Maev, S. V. Morozov, A. A. Moroshek, M. F. Osipenko, M. V. Pavlov, E. V. Parfenchikova, D. V. Ruchkin, A. V. Sazhin, A. A. Smirnov, O. A. Storonova, A. S. Trukhmanov, T. V. Khorobrykh, M. F. Cherkasov, A. L. Shestakov, K. V. Shishin, Yu. V. Embutnieks, V. T. Ivashkin   +38 more
doaj   +1 more source

Diagnostic significance of high resolution esophageal manometry combined with 24-hour pH impedance monitoring for gastroesophageal reflux disease

Di-san junyi daxue xuebao, 2020
Objective To investigate the effect of high resolution esophageal manometry combined with 24-hour esophageal multi-channel pH-impedance monitoring on baseline esophageal impedance in patients with gastroesophageal reflux disease (GERD).
LEI Ge, LIU Xinqun, FAN Xiao, WANG Xuexiang   +3 more
doaj   +1 more source

Preoperative Upper Gastrointestinal Testing Can Help Predicting Long-term Outcome After Gastric Banding for Morbid Obesity [PDF]

, 2018
Background: Gastric banding (GB) is one of the most popular bariatric procedures for morbid obesity. Apart from causing weight loss by alimentary restriction, it can interfere with functions of the esophagus and upper stomach.
Calmes, Jean-Marie, Giusti, Vittorio, Paroz, Alexandre, Suter, Michel   +3 more
core  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Does simultaneous gastric and esophageal pH monitoring increase the diagnosis of gastroesophageal reflux disease?

The Turkish Journal of Pediatrics, 2005
The duration of gastric acidity may affect the interpretation of esophageal pH monitoring study. The aim of this study was to increase the sensitivity of pH monitoring by simultaneous gastric and esophageal pH recording.
Hülya Demir, Hasan Ozen, Nurten Koçak, Inci Nur Saltik-Temizel, Figen Gürakan   +4 more
doaj  

Otolaryngological complications of hypopharyngeal‐esophageal multichannel intraluminal impedance‐pH monitoring

Clinical Case Reports, 2020
Probe of pH study may kink in the esophagus leading to nasal symptoms during the removal.
Francois Bobin, Sven Saussez, Jérôme R. Lechien   +2 more
doaj   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Polycyclic aromatic hydrocarbons and esophageal squamous cell carcinoma [PDF]

, 2012
Esophageal cancer (EC) is the 8th most common cancer and the 6th most frequent cause of cancer mortality worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common type of EC.
Dawsey, S.M., Malekzadeh, R., Roshandel, G., Semnani, S.   +3 more
core