Results 131 to 140 of about 60,263 (313)

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Comorbid Chronic Rhinosinusitis and Asthma: Shared Risk Factors and Treatment Implications—An EAACI Task Force Report

Allergy, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS) and asthma are prevalent conditions that often coexist. These diseases share common inflammatory mechanisms, such as T‐helper cell 2 (T2)‐high inflammation, driven by interleukin (IL)‐4, IL‐5, and IL‐13 cytokines.
Sanna Toppila‐Salmi, Sietze Reitsma, Valérie Hox, Simon Gane, Philippe Gevaert, Juan Maza‐Solano, Alma Helevä, Ida Sulku, Kaisa Santala, Iiris Kangasniemi, Ludger Klimek, Adam Chaker, Aspasia Karavelia, Michael Rudenko, Oliver Pfaar, Laura Van Gerven, Shaari Ariana, Michele Schiappoli, Marie Lundberg, Jan Hagemann, Ibon Eguíluz‐Gracia, Andre Moreira   +21 more
wiley   +1 more source

The Prevalence of Reflux Esophagitis in the Elderly and Its Associated Risk Factors [PDF]

, 2016
Background: Reflux esophagitis is a common problem in the elderly. Compare to the Western Countries, esophageal cancer where reflux esophagitis is the most predominant risk factor is considered rare in Asia.
A Lesmana, Cosmas Rinaldi, Angga, B. (Billy), Lesmana, L. A. (Laurentius), Pakasi, L. S. (Levina), Simanjuntak, W. (Waldemar)   +4 more
core   +1 more source

Codfish Oral Immunotherapy in Children Aged 2–10: Randomized Placebo‐Controlled Study

Allergy, EarlyView.
Codfish OIT significantly increased desensitization in children with fish allergy (43% vs. 11% placebo, p = 0.003), with 69% achieving 10‐fold threshold increases versus 26% in placebo (p = 0.0003). Sustained unresponsiveness remained limited (23% vs. 9%, p = 0.332). Treatment demonstrated acceptable safety with predominantly mild reactions and reduced
Agnes Sze‐yin Leung, Yanjun Gu, Ann Wing‐shan Au, Rosetta Tsz‐ching Leung, Vanessa Hiu‐tung Tang, Kin Yi Fung, Janice Min Li, Christine Yee‐yan Wai, Ting Fan Leung, Gary Wing‐kin Wong   +9 more
wiley   +1 more source

EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation

Open Medicine
Scleroderma is an autoimmune disorder characterized by vasculopathy, progressive skin fibrosis, and dysfunction of internal organs. Esophageal involvement is seen in most scleroderma patients.
Chakraborty Subhankar, Yearsley Martha
doaj   +1 more source

Pediatric Feeding Disorder: Consensus Definition and Conceptual Framework [PDF]

, 2019
Pediatric feeding disorders (PFDs) lack a universally accepted definition. Feeding disorders require comprehensive assessment and treatment of 4 closely related, complementary domains (medical, psychosocial, and feeding skill-based systems and associated
Browne, Joe, Cohen, Sherri S., de Camargo, Olaf Kraus, Delaney, Amy, Dodrill, Pamela, Feuling, Mary B., Gisel, Erika, Goday, Praveen S., Huh, Susanna Y., Kenzer, Amy, Kessler, Daniel B., Lukens, Colleen T., Noel, Richard J., Phalen, James A., Silverman, Alan   +14 more
core   +1 more source

A Case for Anti‐IgE Vaccination

Allergy, EarlyView.
ABSTRACT Immunoglobulin E (IgE) plays a central role in allergic diseases by binding to the high‐affinity receptor FcεRI on mast cells and basophils, where allergen‐induced crosslinking triggers potent inflammatory responses. Various mechanisms by which IgE responses are generated and functionally regulated remain elusive despite many years of research.
Paul Engeroff, Zahra Gharailoo, Monique Vogel, Martin F. Bachmann   +3 more
wiley   +1 more source

Esophageal Lichen Planus—Contemporary Insights and Emerging Trends

Biomedicines
Background: Lichen planus (LP) is a common inflammatory disease affecting skin, mucous membranes, hairs, and nails, with an unpredictable course involving remissions and relapses.
Wolfgang Kreisel, Rebecca Diehl, Annegrit Decker, Adhara Lazaro, Franziska Schauer, Annette Schmitt-Graeff   +5 more
doaj   +1 more source

Epidemiology of Peptic Ulcer Disease: Endoscopic Results of a Systematic Investigation in Iran [PDF]

BACKGROUND Peptic ulcer disease is a multifactorial health problem affecting almost all populations worldwide. Large scale population-based studies are crucial to understanding its scope and specifications in various nations.
برازنده, فرهاد, درخشان, محمدحسین, قاجاریه سپانلو, صدف, ملک زاده, رضا, پورفرضی, فرهاد, یزدانبد, عباس   +5 more
core  

The Efficacy and Medium‐Term Patient‐Reported Outcomes Following Conversion From Sleeve Gastrectomy and Gastric Band to One Anastomoses Gastric Bypass: A Cohort Study

ANZ Journal of Surgery, EarlyView.
In this large single‐centre series, conversional one‐anastomosis gastric bypass was demonstrated to be safe and to deliver meaningful medium‐term weight loss with low morbidity after primary sleeve gastrectomy or gastric banding. While reflux was not universally resolved, patient‐reported satisfaction was high, and secondary enteroenterostomy provided ...
Aaron Lerch, Mokshitha Katneni, Ian Martin   +2 more
wiley   +1 more source