Results 291 to 300 of about 74,143 (357)

Gastric biopsies with prominent eosinophils: Clinicopathologic features and response to therapy

open access: yesHistopathology, Volume 87, Issue 6, Page 880-893, December 2025.
The use of the term ‘histologic eosinophilic gastritis’ (EoG) has been proposed for cases with ≥30 eosinophils/high power field (HPF) in five separate HPF and with no known associated causes of eosinophilia; however, these criteria can miss cases with clinically significant eosinophilia and our study results argue against using this term for pathology ...
Nigar Anjuman Khurram   +2 more
wiley   +1 more source

Small Vessel Vasculitis Mimicking Inflammatory Bowel Disease. [PDF]

open access: yesACG Case Rep J
Puranam K   +6 more
europepmc   +1 more source

Exhaustion‐Resistant CD8 + T Cells in Ankylosing Spondylitis: A Proposed Three‐Axis Model

open access: yesImmunology, Volume 176, Issue 4, Page 409-420, December 2025.
Exhaustion‐resistant CD8+ T cells may sustain ankylosing spondylitis. A three‐axis model—intermittent T‐cell receptor engagement, IL‐15/CD28 co‐stimulation and maintained metabolic fitness—explains how PD‐1^high CD8+ T cells retain effector function and accumulate from gut to entheses, promoting inflammation and aberrant bone remodelling.
Xuhong Zhang   +3 more
wiley   +1 more source

Amyloidosis for the Gastroenterologist: A Comprehensive Systematic Review of Diagnosis and Management of Gastrointestinal Manifestations

open access: yesJournal of Gastroenterology and Hepatology, Volume 40, Issue 12, Page 2842-2856, December 2025.
ABSTRACT Background Amyloidosis is a rare, multisystem disorder characterized by extracellular deposition of misfolded protein fibrils. Gastrointestinal (GI) amyloidosis is uncommon but under‐recognized due to nonspecific symptoms, but early diagnosis is critical to improve quality of life and prognosis.
Myo Jin Tang   +3 more
wiley   +1 more source

Assessment of Esophagogastric Junction Barrier Function With the Supine‐Upright Transition of the Chicago Classification Protocol

open access: yesNeurogastroenterology &Motility, Volume 37, Issue 12, December 2025.
ABSTRACT Background & Aims The straight leg raise (SLR) is a provocative maneuver used to assess the esophagogastric junction (EGJ) barrier function during high‐resolution manometry (HRM) and is part of the Milan Score (MS). The Chicago Classification 4.0 (CCv4.0) protocol requires patients to perform a supine‐upright transition (SUT), increasing intra‐
Stefano Siboni   +17 more
wiley   +1 more source

Optimizing the Straight Leg Raise Maneuver to Improve Prediction of Conclusive Gastro‐Esophageal Reflux Disease

open access: yesNeurogastroenterology &Motility, Volume 37, Issue 12, December 2025.
The SLR maneuver is a valuable component of GERD evaluation. By establishing optimal thresholds for both effective EGJ challenge and accurate GERD prediction, we provide another step for standardized implementation in clinical practice. ABSTRACT Background Gastroesophageal reflux disease (GERD) arises from dysfunction of the anti‐reflux barrier.
Stefano Siboni   +7 more
wiley   +1 more source

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