Results 131 to 140 of about 381,259 (297)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

ESSENCE-Q: Slavic language versions for developmental screening in young children

, 2018
Dejan Stevanovic,1 Rajna Knez,2,3 Tatjana Zorcec,4 Marija Anderluh,5 Jana Kodrič,5 Petar Petrov,6 Feriha Hadžagić Ćatibušić,7 Azra Deljković,8 Slavica Brkic Cvetkovic,1 Nikolina Vrljičak Davidovic,9 Radenka Kuzmanić Šamija,10 Ana Ðorić ...
Anderluh M, Kodrič J, Petrov P, Brkic Cvetkovic S, Vrljičak Davidovic N, Zorcec T, Đorić A, Gillberg C, Stevanovic D, Knez R, Hadžagić Ćatibušić F, Kuzmanić Šamija R, Deljković A   +12 more
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

An inquiry into spatial essence of architectural features through computer-aided abstraction

, 2008
Articulating a comprehensive understanding of existing photographs of built architectural features can provide every architect with a rich visual data base containing all traits of intrinsic essence of architecture that would be a profound resource for ...
Shahzad, Sally Dr, Shahzad, Sally, Parsanezhad, Pouriya   +2 more
core  

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Management of mission critical public safety applications: the 5G ESSENCE Project

, 2019
To address the limitations of legacy Public Safety (PS) solutions, as narrow bandwidth, high deployment cost and poor flexibility, the 5G cellular systems have been proposed. The architecture proposed by the 5G ESSENCE project is based on a cloud-enabled
Pérez Romero, Jordi, Spada, Maria Rita, Vincenzo Riccobene, M. R. Spada, Ruben Solozabal, J. Perez-Romero, Riccobene, Vincenzo, Sanchoyerto, Aitor, Solozabal, Ruben, Aitor Sanchoyerto, M. A. Kourtis, kourtis, Michail-Alexandros   +11 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source