Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The new era of MASH pharmacotherapy: a comprehensive review of FDA-approved and emerging agents. [PDF]
Front Gastroenterol (Lausanne)Qasim A, Alataa R, Veena F, Shehi E.
europepmc +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
The ESSENCE of hope: what semaglutide's Food and Drug Administration approval means for metabolic dysfunction-associated steatohepatitis. [PDF]
Hepatobiliary Surg NutrAlamgir M, Sohal A, Kowdley KV.
europepmc +1 more source
'A Moment for Me': The Role of Respite in Sustaining Mental Health Carers. [PDF]
Int J Ment Health NursAlmoaber Z +3 more
europepmc +1 more source
Post-exercise rehydration: a randomized cross-over trial comparing a 100% fruit juice, a glucose-based sports drink, and water. [PDF]
J Int Soc Sports NutrJuett LA +9 more
europepmc +1 more source
Appropriateness and utility of a clinical decision support system at the digital front door. [PDF]
NPJ Digit MedPimenta A +10 more
europepmc +1 more source
Correction: A micro-CT-integrated 3D simulation framework reveals fluid transport mechanisms and void dynamics in root canal fillings. [PDF]
Sci RepRaoof A +4 more
europepmc +1 more source