Results 71 to 80 of about 178,431 (232)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Essence

, 2013
State-of-the-art faceted search graphical user interfaces for digital libraries provide a wide range of filters perfectly suitable for narrowing down results for well-defined user needs. However, they fail to deliver summarized overview information for users that need to familiarize themselves with a new scientific topic.
Homoceanu, Silviu, Tönnies, Sascha, Wille, Philipp, Wolf-Tilo Balke   +3 more
openaire   +2 more sources

SOBRE A ESSÊNCIA E FORMA LÓGICA DA NORMA JURÍDICA NA TEORIA GERAL DO DIREITO CONTEMPORÂNEA [PDF]

Revista Acadêmica, 2020
The present paper aims at analyzing legal norms in order to determine their essence and logical form. To this purpose, it will engage in the analysis of the relationship between the totality of the legal system and ...
Guilherme Barcelos Machado Lopes
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

L’écriture du corps dessiné dans Il cavaliere inesistente

Italies, 2012
Il cavaliere inesistente pose clairement le problème de l’écriture, grâce à un personnage écrivain, Suor Teodora. Cette narratrice cloîtrée est la version féminine des moines enlumineurs : écriture et dessin sont donc unis dans cet univers clos comme ...
Judith Obert
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Cause and essence [PDF]

Synthese, 1992
Essence and causation are fundamental in metaphysics, but little is said about their relations. Some essential properties are of course causal, as it is essential to footprints to have been caused by feet. But I am interested less in causation's role in essence than the reverse: the bearing a thing's essence has on its causal powers.
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Security in definitional terms

Journal of Modern Science
The sense of security constitutes one of the fundamental human needs. Due to the crucial role that security plays in the contemporary world and its impact on states, societies, and individuals, it is often a subject of analysis in scientific literature ...
Leszek Goździewski
doaj   +1 more source