Results 71 to 80 of about 1,014,541 (262)

Availability of Analgesic and Anti-Inflammatory Medicines in Primary Health Care

Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022
Objective: To describe and analyze the availability and factors related to the presence of analgesics and non-steroidal anti-inflammatory drugs in the Brazilian public primary healthcare system.
Jacqueline Silva Santos, Alex Junio Silva da Cruz, Lia Silva de Castilho, Mauro Henrique Nogueira Guimarães Abreu   +3 more
doaj  

Drug Utilization Pattern by Using WHO Core Prescribing Indicators in Orthopedics and Obstetrics / Gynecology Departments of a Tertiary Care Hospital

Journal of Lumbini Medical College, 2019
Introduction: Drug utilization research is an important tool to facilitate rational use of drugs. In low income countries irrational use of drugs is a common problem like overuse of drugs and inappropriate use of antibiotics, leading to poor treatment ...
Naresh Karki, Ruban Raj Joshi, Buddhi Kumar Shrestha, Pravin Prasad   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Drug Therapetics

Journal of Nepal Medical Association, 2003
Balkrishna Khakurel
doaj   +1 more source

Assistência farmacêutica na atenção básica de saúde: a experiência de três estados brasileiros

Cadernos de Saúde Pública
No contexto das mudanças ocorridas no sistema de fornecimento de medicamentos em nível nacional no Brasil, com destaque para a desativação da Central de Medicamentos (CEME), e da crescente descentralização das ações de saúde no âmbito do Sistema Único de
Marly Aparecida Elias Cosendey, Jorge Antônio Zepeda Bermudez, André Luis de Almeida dos Reis, Hayne Felipe da Silva, Maria Auxiliadora Oliveira, Vera Lúcia Luiza   +5 more
doaj  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Profile of continuous use drugs prescribed in primary health care and presence in list of essential drugs

Revista de Ciências Farmacêuticas Básica e Aplicada, 2021
Objectives: To evaluate the profile of the drugs for continuous use prescribed in Primary Health Care (PHC) in Santa Rosa / RS and to identify presence in the official lists of essential drugs. Methods: Cross-sectional, analytical and quantitative study,
Paula Lorenzoni Nunes, Vanessa Adelina Casali Bandeira, Vanessa Boeira Flores, Andressa Oss-Emer Soares Bottega, Karine Raquel Uhdich Kleibert, Christiane de Fátima Colet   +5 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source