Results 101 to 110 of about 2,992,939 (247)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

TEHIP news, issue no. 3 : completing the circle; bringing research into development

, 2000
"A newsletter of the IDRC/MOH Tanzania Essential Health Interventions Project"The knowledge being generated by the Tanzania Essential Health Interventions Project (TEHIP) in research and development interventions has demonstrated the benefits of evidence-
Tanzania Essential Health Interventions Project
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Welcome enhancements: responding to feedback to deliver enhancements with impact.

, 2022
This paper will cover RGU's institutional welcome, with a focus on the delivery of the Semester 1 2021 welcome offer, the evaluation of this project, and the actions taken as a result to make enhancements for the delivery of Semester 2's 2022 welcome ...
Massie, Daniel
core   +2 more sources

Enhancing dynamical system modeling through interpretable machine-learning augmentations: a case study in cathodic electrophoretic deposition

Data-Centric Engineering
We introduce a comprehensive data-driven framework aimed at enhancing the modeling of physical systems, employing inference techniques and machine-learning enhancements.
Christian Jacobsen, Jiayuan Dong, Mehdi Khalloufi, Xun Huan, Karthik Duraisamy, Maryam Akram, Wanjiao Liu   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

TEHIP news, vol. 1, no. 1, January - June 1999 : on evidence-based planning; testing a process

, 1999
"A newsletter of the IDRC/MOH Tanzania Essential Health Interventions ...
Tanzania Essential Health Interventions Project
core   +1 more source

First results of ionospheric plasma blob observations in the African topside ionosphere during a deep solar minimum using Swarm satellites

Frontiers in Astronomy and Space Sciences
This study presents the first comprehensive investigation of low-latitude ionospheric plasma blobs in the African sector during the deep solar minimum period from January 2018 to December 2020, using data from the Swarm satellite mission.
Oluwasegun M. Adebayo, Babatunde Rabiu, Babatunde Rabiu, Alexandre A. Pimenta, Abraham C.-L. Chian, Abraham C.-L. Chian, Oluwakemi Dare-Idowu, Daniel I. Okoh, Daniel I. Okoh, Aderonke Akerele   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source