Results 71 to 80 of about 2,992,939 (247)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Essential Oils

, 2020
Essential oils are natural compounds obtained from plants with powerful biological activities. Several studies have reported their use as food additives due to their actions as antimicrobial and antioxidant agents. Despite some limitations, such as aroma
Ribeiro-Santos, Regiane, Ana Sanches-Silva, Regiane Ribeiro-Santos, Sanches-Silva, Ana, Mariana Andrade, Andrade, Mariana   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Spatial-temporal load prediction of electric bus charging station based on S2TAT

International Journal of Electrical Power & Energy Systems
In recent years, electric buses have advanced rapidly due to their green and low-carbon attributes. To address range anxiety and optimize charging strategies, accurately predicting charging load has become essential.
Guangnian Xiao, Hailin Tong, Yaqing Shu, Anning Ni   +3 more
doaj   +1 more source

ELECTROCHEMICAL MACHINING OF ADVANCED MATERIALS - A REVIEW

Nonconventional Technologies Review, 2023
For electrochemical machining (ECM) to be stable and accurate, the electrolytic flow field is essential. To improve the flow field, numerous studies have been conducted.
Titi Danciu, Liviu Daniel Ghiculescu
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Enhancing SR-Tree for Nearest Neighbor Search

IEEE Access
Nearest neighbor search, also known as k-nearest neighbors (kNN), has become one of the essential backbones in machine learning and data mining tasks, particularly in multidimensional dynamic and evolving data environments. While dynamic index structures
Kayumov Abduaziz, Shincheol Lee, Ji Sun Shin   +2 more
doaj   +1 more source

A Learning Community Involving Collaborative Course-Based Research Experiences for Foundational Chemistry Laboratories

Education Sciences, 2020
Numerous American national committees have recommended the replacement of traditional labs with a more engaging curriculum that inspires inquiry and enhances scientific skills (examples include the President’s Council of Advisors on Science and ...
David M. Rubush, Kari L. Stone
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source