Results 101 to 110 of about 683,747 (361)

Extracorporeal Catalytic Hemoperfusion Therapy for Refractory Septic Shock Using Ceria Nanoparticle‐Embedded Porous Microbeads

Advanced Functional Materials, EarlyView.
This study introduces an extracorporeal hemoperfusion system incorporating porous microbeads embedded with autocatalytic ceria nanoparticles (CeNPs) for targeted reactive oxygen species (ROS) scavenging in septic shock. The blood‐compatible hemoperfusion cartridge demonstrated significant improvements in survival, hemodynamic stability, and organ ...
Pilseon Im, Han‐Gil Jeong, Donghee Kim, Jimin Song, Ngoc Man Phan, Eun‐seo Choi, Young‐Min Kim, Seo‐Hyeon Jeong, Jooho Park, Inwon Park, Jaeyun Kim   +10 more
wiley   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Polymorphisms in the WNK1 gene are asociated with blood pressure variation and urinary potassium excretion [PDF]

, 2009
WNK1 - a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control - is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using
Brown, M, Brunner, E, Burke, B, Cappucio, FP, Caulfield, M, Chambers, J, Clarke, R, Collins, R, Connell, JM, Dobson, R, Dominiczak, AF, Elliott, P, Eyheramendy, S, Farrall, M, Hoti, M, Howard, P, Iacone, R, Ji, C, Juhanson, P, Kooner, J, Kumari, M, Laan, M, Lathrop, GM, Lee, K, Marmot, M, Munroe, PB, Newhouse, S, Onipinla, A, Org, E, Samani, NJ, Shaw-Hawkins, S, Strazzullo, P, Veldre, G, Viigimaa, M, Wallace, C   +34 more
core  

Reduced Cardiovascular Reserve in Chronic Kidney Failure: A Matched Cohort Study [PDF]

, 2015
Background: Patients with chronic kidney failure (CKF) experience impaired functional cardiovascular reserve with reduced oxygen consumption at peak exercise (Vo2peak).
Aldridge, N, Banerjee, P, Bland, R, Fletcher, S, Hamborg, T, Higgins, RM, Imray, C, Koganti, S, Krishnan, NS, Lim, K, McGregor, G, Oxborough, D, Ting, SMS, Townend, J, Zehnder, D   +14 more
core   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Comparison of Anti Hypertensive Effect of Fixed Dose Enalapril and Losartan in Essential Hypertension

Journal of Rawalpindi Medical College, 2009
Background: Angiotensin converting enzyme inhibitors and angiotensin receptor blockers are being extensively used these days for treatment of mild to moderate hypertension. The selection of either of the two drugs is usually based on physician preference.
Khurram Mansoor
doaj  

Posterior Reversible Encephalopathy Syndrome and Azathioprine [PDF]

, 2019
Posterior reversible encephalopathy syndrome (PRES) is a rare syndrome that presents with neurological manifestations, often associated with arterial hypertension.
Corte-Real, A, Vilas-Boas, S
core   +2 more sources

Engineered 3D Kidney Glomerular Microtissues to Model Podocyte‐Centric Diseases for the Validation of New Drug Targets

Advanced Healthcare Materials, EarlyView.
The study introduces innovative 3D microtissues that replicate the glomerular filtration barrier of the kidney, offering a novel platform for understanding podocytopathies. These microtissues simulate the glomerulus's structure and dynamics, allowing for the modeling of podocyte injuries and drug testing.
Sara Buttό, Solange Vidal, Xi Rui Zeng, Martin Rausch, Immihan Ceren Yasa, Magali P. Ferro   +5 more
wiley   +1 more source

Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension

International Journal of Hypertension, 2012
Hyperhomocysteinemia (hHcy) has been associated with an increased risk of cardiovascular disease and stroke. Essential hypertension (EH), a polygenic condition, has also been associated with increased risk of cardiovascular related disorders.
Javed Y. Fowdar, Marta V. Lason, Attila L. Szvetko, Rodney A. Lea, Lyn R. Griffiths   +4 more
doaj   +1 more source

Intelligent Incident Hypertension Prediction in Obstructive Sleep Apnea [PDF]

arXiv
Obstructive sleep apnea (OSA) is a significant risk factor for hypertension, primarily due to intermittent hypoxia and sleep fragmentation. Predicting whether individuals with OSA will develop hypertension within five years remains a complex challenge.
arxiv