Results 121 to 130 of about 1,901,618 (330)

Modelos de mapas topográficos y acústicos: del papel al ordenador

open access: yesModelling in Science Education and Learning, 2013
The capacity and computing power of programs like Matlab enables first year students of a college degree are able to model using the computer both topographic maps and roads on them, as acoustic maps.
Anna Vidal   +5 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

The daily dynamic potential accessibility by car in London on Wednesdays

open access: yesJournal of Maps, 2017
The map presented in this paper shows the effect of congestion on daily accessibility in the London metropolitan area on Wednesdays. Because of its dynamic nature, it is challenging to both calculate the effects of this phenomenon and to represent it ...
Borja Moya-Gómez   +1 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

GEOGRAPHICAL SIMULTANEITY: A NEW INDEX TO VALIDATE RESULTS OBTAINED FROM DIGITAL IMAGE PROCESSING OF THEMATIC MAPS

open access: yesRevista Brasileira de Cartografia, 2017
New technologies have enabled the dissemination of maps. Maps are commonly produced either by sophisticated image processing techniques or by more conventional methods.
Ardemirio de Barros Silva   +2 more
doaj  

Essential maps exist from 𝐵𝑈 to 𝐶𝑜𝑘𝑒𝑟𝐽 [PDF]

open access: yesProceedings of the American Mathematical Society, 1986
We show that [ BU,coker J ] ≠ 0 [{\text {BU,coker}}\,J] \ne 0 but that there are no infinite loop maps from BU to coker J J . The proofs involve the Segal conjecture.
openaire   +2 more sources

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy