Results 161 to 170 of about 1,990,830 (333)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

T4 Cardiac fibroblast P38α map kinase is essential for cardiomyocyte hypertrophy and cardiac dysfunction following myocardial injury

, 2016
SA Bageghni, Karen E. Hemmings, KE Porter, JFX Ainscough, MJ Drinkhill, NA Turner   +5 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Hsp90 and phosphorylation of the Slt2(Mpk1) MAP kinase activation loop are essential for catalytic, but not non-catalytic, Slt2-mediated transcription in yeast [PDF]

, 2022
Stefan H. Millson, Andrew W. Truman, Peter W. Piper   +2 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

An operational framework to map Essential Life Support Areas (ELSAs) for biodiversity, climate, and sustainable development [PDF]

Oscar Venter, Jamison Ervin, Anne Virnig, Scott Atkinson, Marion Marigo, Di Zhang, Christina Supples, Enrique Paniagua Arís, Lloyd Phillips, Richard Schuster, Xavier Corredor Llano, Genevieve Pence, Peter Arcese, Luizmar de Assis Barros, Aray Belgubaeva, D. Borja, Steve Brumby, Neil D. Burgess, Leticia Cardozo, Carlos Vega, Maria Veronica Cordova, Liliana Corzo, Esteban Delgado-Altamirano, Catarina Fonseca, Edward T. Game, Yvio Georges, Hedley S. Grantham, Daniel Jesús Munoz Guerra, Andrew J. Hansen, Greer Hawley, N.B. van den Hout, Berexford Jallah, Deepak Kc, William Llactayo Leon, Leslie James, Dy Lihong, Casandra Llosa, Abu Rushed Jamil Mahmood, Tsepang Makholela, Mark Mathis, Cornelia Miller Granados, Jennifer McGowan, Robert Monge, Nokutula Mhene, Violeta Muñoz‐Fuentes, Sandra Neubert, Menaka Panta Neupane, Fabiola Nuñez Neyra, Diego Olarte, Emmanuel Temitope Olatunji, Dipen Paul, Verónica Recondo, G. Pierre, Hugh P. Possingham, Susana Rodríguez‐Buriticá, Kanat Samarkhanov, Vijaya Singh, Arnout van Soesbergen, Talgat Taukenov, David Telcy, Cristina Telhado, E. Abraham T. Tumbey, Piero Visconti, Hólger Zambrano, James Watson   +64 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

3P303 Exploring to the network configuration of essential metabolic maps

, 2005
Yusuke Azuma, Mitsutoshi Ota
openalex   +2 more sources

A Population of Navigator Neurons Is Essential for Olfactory Map Formation during the Critical Period [PDF]

, 2018
Yunming Wu, Limei Ma, Kyle Duyck, Carter C. Long, Andrea Moran, Hayley Scheerer, Jillian F Blanck, Allison Peak, Andrew Box, Anoja Perera, C. Ron Yu   +10 more
openalex   +1 more source