Results 191 to 200 of about 1,901,618 (330)

Phosphoinositide 3-Kinase–Dependent Membrane Recruitment of P62dok Is Essential for Its Negative Effect on Mitogen-Activated Protein (Map) Kinase Activation [PDF]

, 2001
Mingming Zhao, Arndt A. Schmitz, Yi Qin, Antonio Di Cristofano, Pier Paolo Pandolfi, Linda Van Aelst   +5 more
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Bio-Based and Nanostructured Polymers for Sustainable Protection of Cultural Heritage and Medicinal Crops: Convergence of Heritage Science, Circular Bioeconomy, and Environmental Protection. [PDF]

Polymers (Basel)
Fierascu I, Baroi AM, Matei RI, Fistos T, Chican IE, Enascuta CE, Avramescu SM, Fierascu RC.   +7 more
europepmc   +1 more source

The Candida auris Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence [PDF]

Raju Shivarathri, Manju Chauhan, Abhishek Datta, Diprasom Das, Adela Karuli, Sabrina Jenull, Karl Kuchler, Shankar Thangamani, Anuradha Chowdhary, Jigar V. Desai, Neeraj Chauhan   +10 more
openalex   +1 more source

CPMK2, an SLT2‐homologous mitogen‐activated protein (MAP) kinase, is essential for pathogenesis of Claviceps purpurea on rye: evidence for a second conserved pathogenesis‐related MAP kinase cascade in phytopathogenic fungi [PDF]

, 2002
Géraldine Mey, Katrin Held, Jan Scheffer, Klaus B. Tenberge, Paul Tudzynski   +4 more
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Leveraging RegNet and CBAM for precise detection of honey adulteration using thermal image analysis. [PDF]

Sci Rep
Ilias B, Abdelaziz B, Anas EN, Douzi S, Douzi H.   +4 more
europepmc   +1 more source

Essential Error Analysis of Self-Localization From Map Structure in Urban Environment [PDF]

Yuki Endo, Shunsuke Kamijo
openalex   +1 more source

Functional Genomics on Potato Virus A: Virus Genome-Wide Map of Sites Essential for Virus Propagation [PDF]

, 2002
Tuija Kekarainen, Harri Savilahti, Jari P. T. Valkonen   +2 more
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source