Results 201 to 210 of about 6,492,121 (341)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Integrating geographic information systems into veterinary education within the one health framework: an interdisciplinary approach. [PDF]

Front Vet Sci
Contreras A, Cuevas V, Rivera-Gomis J, Sánchez A, Acevedo P, Vicente J.   +5 more
europepmc   +1 more source

Phosphoinositide 3-Kinase–Dependent Membrane Recruitment of P62dok Is Essential for Its Negative Effect on Mitogen-Activated Protein (Map) Kinase Activation [PDF]

, 2001
Mingming Zhao, Arndt A. Schmitz, Yi Qin, Antonio Di Cristofano, Pier Paolo Pandolfi, Linda Van Aelst   +5 more
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Visual Thinking to Explore "Relational Pharmacology": Systemic Maps for Managing Non-Selective Antidepressants in Cardiovascular Prevention. [PDF]

Pharmacy (Basel)
García-Domínguez I, Rodríguez-Luna A, Machuca M.   +2 more
europepmc   +1 more source

The Candida auris Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence [PDF]

Raju Shivarathri, Manju Chauhan, Abhishek Datta, Diprasom Das, Adela Karuli, Sabrina Jenull, Karl Kuchler, Shankar Thangamani, Anuradha Chowdhary, Jigar V. Desai, Neeraj Chauhan   +10 more
openalex   +1 more source

Analysis of the Activity-Deprived Zebrafish MutantmachoReveals an Essential Requirement of Neuronal Activity for the Development of a Fine-Grained Visuotopic Map [PDF]

, 2001
Lara Gnuegge, Susanne Schmid, Stephan C. F. Neuhauss   +2 more
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Improved optimization based on parrot's chaotic optimizer for solving complex problems in engineering and medical image segmentation. [PDF]

Sci Rep
Sayyouri A, Bencherqui A, Mansouri H, Karmouni H, Moustabchir H, Sayyouri M, Bourkane A, Cherkaoui A, Askar SS, Abouhawwash M.   +9 more
europepmc   +1 more source

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Nature, 2008
A. Meissner, T. Mikkelsen, H. Gu, Marius Wernig, J. Hanna, A. Sivachenko, Xiaolan Zhang, B. Bernstein, C. Nusbaum, D. Jaffe, A. Gnirke, R. Jaenisch, E. Lander   +12 more
semanticscholar   +1 more source