CPMK2, an SLT2‐homologous mitogen‐activated protein (MAP) kinase, is essential for pathogenesis of Claviceps purpurea on rye: evidence for a second conserved pathogenesis‐related MAP kinase cascade in phytopathogenic fungi [PDF]
, 2002 Géraldine Mey +4 more
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
A framework for EO-based National Agricultural Monitoring (EO-NAM) for the African Context. [PDF]
NPJ Sustain AgricNakalembe C +7 more
europepmc +1 more source
MAP kinase phosphatase-1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution [PDF]
Sean M. Fortier +9 more
openalex +1 more source
Functional Genomics on Potato Virus A: Virus Genome-Wide Map of Sites Essential for Virus Propagation [PDF]
, 2002 Tuija Kekarainen +2 more
openalex +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
The relationship between geochemical background values of MgO and SiO₂ and regional population longevity: evidence from Yunnan, China. [PDF]
Front Public HealthZhou X, Wang J, Zhu S, Lai M.
europepmc +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Spatial features of tumor-infiltrating lymphocytes in primary lesions of lung adenocarcinoma predict lymph node metastasis. [PDF]
J Transl MedZhang H +6 more
europepmc +1 more source
Ground Data are Essential for Biomass Remote Sensing Missions
Surveys in geophysics, 2019 J. Chave +16 more
semanticscholar +1 more source