Results 281 to 290 of about 1,901,618 (330)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Integrating geographic information systems into veterinary education within the one health framework: an interdisciplinary approach. [PDF]

Front Vet Sci
Contreras A, Cuevas V, Rivera-Gomis J, Sánchez A, Acevedo P, Vicente J.   +5 more
europepmc   +1 more source

A hybrid deep learning framework for skin disease localization and classification using wearable sensors. [PDF]

PeerJ Comput Sci
Zhao X, Zhang H, Zheng Q, Jing C.
europepmc   +1 more source

Phytochemical profile and antioxidant activity of Dracocephalum kotschyi boiss. affected by environmental conditions of cultivation regions. [PDF]

BMC Plant Biol
Zamani S, Bakhshi D, Ebadi MT, Sahraroo A.   +3 more
europepmc   +1 more source

Enhancing spatial perception in robot-assisted minimally invasive surgery with edge-preserving depth estimation and pose tracking. [PDF]

BMC Surg
Guan B, Zhao J, Yi B, Li J.
europepmc   +1 more source

Clinical and biochemical characterization of a patient with prolidase deficiency, a rare disorder of collagen metabolism. [PDF]

Mol Genet Metab Rep
Coody TK, De Biase I, Porter JM, Pasquali M, Shayota BJ.   +4 more
europepmc   +1 more source

Toward Acoustic-Based Normalization of Laryngeal EMG for Improved Interspeaker Consistency in Muscle-to-Acoustic Mapping. [PDF]

J Voice
Martínez JD, Ibarra EJ, Parra JA, Mehta DD, Heaton JT, Hillman RE, Plocienniczak MJ, Cooper JC, Zañartu M.   +8 more
europepmc   +1 more source

Confidence-guided cryo-EM map optimisation with LocScale-2.0

Bharadwaj A, de Bruin R, Jakobi AJ.
europepmc   +1 more source