Results 231 to 240 of about 451,267 (297)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Availability of essential medicines for maternal health in public health facilities of the Mwanza region, northwestern Tanzania. [PDF]

J Med Access
Mayunga C, Msaki E, Katabalo D, Mwita S.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Availability of essential medicines, inventory management practices, and related challenges in internally displaced persons (IDP) camps, eastern Amhara, Ethiopia: an explanatory sequential mixed study. [PDF]

Confl Health
Alemayehu TT, Woldeyohanins AE, Gebremeskel ED, Geremew GW, Wassie YA, Mekete MD, Minwagaw T, Abebe TB, Seifu K.   +8 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

An evaluation of the adequacy of Indian national and state essential medicines lists (EMLs) for palliative care medical needs-a comparative analysis. [PDF]

Ecancermedicalscience
Agrawal D, Shrinivas D, Sharma P, Rajagopal MR, Ghoshal A, Zadey S.   +5 more
europepmc   +1 more source

Getting Real About Essential Medicines: The Last Kilometer [PDF]

, 2016
White, Lucie
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Availability, cost and affordability of essential medicines for smoking cessation in low-income and middle-income countries: a cross-sectional study. [PDF]

Thorax
Plum C, Stolbrink M, Ozoh O, Jayasooriya S, Nightingale R, Mortimer K, Halpin D.   +6 more
europepmc   +1 more source

Exploring access to essential medicines in the South Pacific: insights from a multi-country cross-sectional study. [PDF]

Lancet Reg Health West Pac
Oldfield L, Penm J, Moles R.
europepmc   +1 more source