Results 81 to 90 of about 451,267 (297)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The Doha Declaration Ten Years on and Its Impact on Access to Medicines and the Right to Health [PDF]

, 2011
Access to medicines is a human right, enshrined in legally binding international human rights treaties, select regional agreements and numerous national constitutions. The realization of access to medicines, including antiretroviral treatment, as part of
Correa, C, Matthews, DN
core  

Health-industry linkages for local health: reframing policies for African health system strengthening [PDF]

, 2018
The benefits of local production of pharmaceuticals in Africa for local access to medicines and to effective treatment remain contested. There is scepticism among health systems experts internationally that production of pharmaceuticals in sub-Saharan ...
ACT Watch Group, African Union, African Union, African Union, African Union, Aldis, Battams, Berger, Bigdeli, Boschma, Chataway, Chaudhuri, Cohen, Commission on Social Determinants of Health (CSDH), Dinh, East African Community (EAC), Eriksen, Ernst, Ewen, Federal Democratic Republic of Ethiopia (FDRE), Flahault, Gebre-Mariam, Geoffrey Banda, Giddens, Government of Kenya, Government of Uganda, Hahn, Horton, Institute for Health Metrics and Evaluation (IHME), Jires Tunguhole, Julius Mugwagwa, Kaplan, Kaplan, Koplan, Kumar, Lin, Lopes, Macfarlane, Mackintosh, Mackintosh, Mackintosh, Malmberg, Maureen Mackintosh, Mercy Karimi Njeru, Ministry of Industry (MIT) and UNIDO, Morris, Mujinja, Nadvi, Ozawa, Paula Tibandebage, Ravix, Republic of Ghana, Republic of Kenya, Rowson, Rushton, Samuel Wangwe, Schmitz, Seiter, Shadlen, Sheikh, Shiffman, Sidibé, Srinivas, Sutton, UNCTAD, United Nations (UN), United Republic of Tanzania (URT), United Republic of Tanzania (URT), Waako, Wagner, West, WHO/World Bank, Wiedenmayer, Wilson, Wirtz, World Health Organisation (WHO), World Health Organisation (WHO), World Health Organisation (WHO), World Health Organisation (WHO), World Health Organisation (WHO), Yadav, Yadav   +81 more
core   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Justiciability of the Right to Health: access to medicines - the South African and Indian experience [PDF]

, 2009
The World Health Organisation (WHO) estimates that the share of people lacking access to essential medicines worldwide is around 1.7 billon, approximately one-third of the world’s population. Lack of access to essential medicines is an especially serious
Sellin, J. (Jennifer)
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Doha Round’s Public Health Legacy: Strategies for the Production and Diffusion of Patented Medicines Under the Amended TRIPS Provisions [PDF]

, 2007
This entry into force of the World Trade Organization (WTO) TRIPS Agreement in 1995 transformed the international intellectual property system. The harmonization of basic intellectual property standards has operated to protect investment in innovation ...
Abbott, Frederick M., Reichman, Jerome H.   +1 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Immunogenic Modulations Induced by Prospective Anti-Malarial Herbal Extracts in Murine Model [PDF]

, 2010
Keeping in view the ever increasing problem of drug resistance and affordability of the antimalarial drugs by the poor mass, herbal medicines can become an important and alternative sustainable strategy for malaria treatment.
Chinmoy Karjee, Dipankar Singha, Guruprasad Mandal, Manoj Das, Niladri Sekhar Bhunia, Sajal Ray, Sanat Biswas, Shyamal Das Gupta, Sreemayee Sarkar, Sudipta Chakraborty, Suman Mukherjee, Swapna Chhetri   +11 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source