Results 111 to 120 of about 227,935 (279)

Health-industry linkages for local health: reframing policies for African health system strengthening [PDF]

, 2018
The benefits of local production of pharmaceuticals in Africa for local access to medicines and to effective treatment remain contested. There is scepticism among health systems experts internationally that production of pharmaceuticals in sub-Saharan ...
ACT Watch Group, African Union, African Union, African Union, African Union, Aldis, Battams, Berger, Bigdeli, Boschma, Chataway, Chaudhuri, Cohen, Commission on Social Determinants of Health (CSDH), Dinh, East African Community (EAC), Eriksen, Ernst, Ewen, Federal Democratic Republic of Ethiopia (FDRE), Flahault, Gebre-Mariam, Geoffrey Banda, Giddens, Government of Kenya, Government of Uganda, Hahn, Horton, Institute for Health Metrics and Evaluation (IHME), Jires Tunguhole, Julius Mugwagwa, Kaplan, Kaplan, Koplan, Kumar, Lin, Lopes, Macfarlane, Mackintosh, Mackintosh, Mackintosh, Malmberg, Maureen Mackintosh, Mercy Karimi Njeru, Ministry of Industry (MIT) and UNIDO, Morris, Mujinja, Nadvi, Ozawa, Paula Tibandebage, Ravix, Republic of Ghana, Republic of Kenya, Rowson, Rushton, Samuel Wangwe, Schmitz, Seiter, Shadlen, Sheikh, Shiffman, Sidibé, Srinivas, Sutton, UNCTAD, United Nations (UN), United Republic of Tanzania (URT), United Republic of Tanzania (URT), Waako, Wagner, West, WHO/World Bank, Wiedenmayer, Wilson, Wirtz, World Health Organisation (WHO), World Health Organisation (WHO), World Health Organisation (WHO), World Health Organisation (WHO), World Health Organisation (WHO), Yadav, Yadav   +81 more
core   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Availability, affordability and costs of pediatric medicines in Mongolia

BMC Pediatrics, 2018
Background The Essential Medicines List for Children (EMLc) was developed by the World Health Organization (WHO) to assist member countries to achieve Millennium Development Goals (MDG).
Gereltuya Dorj, Bruce Sunderland, Tsetsegmaa Sanjjav, Gantuya Dorj, Byambatsogt Gendenragchaa   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Essential medicines: An Indian perspective

Indian Journal of Community Medicine, 2015
The concept of defining essential medicines and establishing a list of them was aimed to improve the availability of affordable medicines for the world′s poor. Access to essential medicines is a major determinant of health outcomes.
Rituparna Maiti, Vikas Bhatia, Biswa Mohan Padhy, Debasish Hota   +3 more
doaj   +1 more source

Review of medicine registration system in Tanzania [PDF]

, 2019
Philosophiae Doctor - PhDRegistration of medicines is an essential function of the national medicine regulatory system of any country. Since the start of the medicine registration system in Tanzania in early 2000s, no systematic review has been carried
KISOMA, SUNDAY
core  

Prescribing indicators at primary health care centers within the WHO African region: a systematic analysis (1995-2015) [PDF]

, 2016
Background Rational medicine use is essential to optimize quality of healthcare delivery and resource utilization. We aim to conduct a systematic review of changes in prescribing patterns in the WHO African region and comparison with WHO indicators in ...
A Bexell, A Cameron, A Cameron, A de-Graft Aikins, A Fugh-Berman, A Kotwani, A Massele, A Massele, A Massele, A Sisay, Allyson M. Pollock, AS Kesselheim, AS Oyeyemi, AY Massele, AY Massele, AY Massele, B Godman, B Godman, B Trap, B Tsega, BS Uzochukwu, C Babalola, C Llor, C Paton, CE Nwolisa, CR Polage, D Adeloye, D Afriyie, D Cousineau, D Maher, D Moher, DE Ball, DK Afriyie, E Boonstra, E Boonstra, E Enato, E Nicolosi, EP Whitlock, G Krause, G Mohlala, G Shiferaw, Global Burden of Disease Study C, H Dippenaar, H Wang, Harvard Medical School and Harvard Pilgrim Health, HV Hogerzeil, I Tamuno, I Truter, J Dumoulin, JC Meyer, JJ Gagne, KA Holloway, L Bantie, L Savadogo, LL Gustafsson, M Abuelkhair, M Angamo, M Veronin, M Woerkom, MA Ahiabu, N Katende-Kyenda, O Odusanya, P Kapp, PA Phillips-Howard, Petra Brhlikova, R Adisa, R Laing, R Laing, R Narendran, R Ofori-Asenso, R Risk, Richard Ofori-Asenso, RJ Dagli, RS Md Rezal, S Abdella, S Fraser, S Nsimba, S Suleman, SE Nsimba, SH Downs, SM Patterson, SO Olayemi, SP Fitzgerald, TG Lueder von, V Velkoff, WK Bosu, World Health Organization, World Health Organization, World Health Organization, World Health Organization, World Health Organization Regional Office for Africa, X Yin, Z Desta   +92 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source