Results 81 to 90 of about 227,175 (284)

Health-industry linkages for local health: reframing policies for African health system strengthening [PDF]

, 2018
The benefits of local production of pharmaceuticals in Africa for local access to medicines and to effective treatment remain contested. There is scepticism among health systems experts internationally that production of pharmaceuticals in sub-Saharan ...
ACT Watch Group, African Union, African Union, African Union, African Union, Aldis, Battams, Berger, Bigdeli, Boschma, Chataway, Chaudhuri, Cohen, Commission on Social Determinants of Health (CSDH), Dinh, East African Community (EAC), Eriksen, Ernst, Ewen, Federal Democratic Republic of Ethiopia (FDRE), Flahault, Gebre-Mariam, Geoffrey Banda, Giddens, Government of Kenya, Government of Uganda, Hahn, Horton, Institute for Health Metrics and Evaluation (IHME), Jires Tunguhole, Julius Mugwagwa, Kaplan, Kaplan, Koplan, Kumar, Lin, Lopes, Macfarlane, Mackintosh, Mackintosh, Mackintosh, Malmberg, Maureen Mackintosh, Mercy Karimi Njeru, Ministry of Industry (MIT) and UNIDO, Morris, Mujinja, Nadvi, Ozawa, Paula Tibandebage, Ravix, Republic of Ghana, Republic of Kenya, Rowson, Rushton, Samuel Wangwe, Schmitz, Seiter, Shadlen, Sheikh, Shiffman, Sidibé, Srinivas, Sutton, UNCTAD, United Nations (UN), United Republic of Tanzania (URT), United Republic of Tanzania (URT), Waako, Wagner, West, WHO/World Bank, Wiedenmayer, Wilson, Wirtz, World Health Organisation (WHO), World Health Organisation (WHO), World Health Organisation (WHO), World Health Organisation (WHO), World Health Organisation (WHO), Yadav, Yadav   +81 more
core   +3 more sources

The human right to medicines [PDF]

, 2008
This article considers the component of the right to the highest standard of health that relates to medicines, including essential medicines. Using the right-to-health analytical framework that has been developed in recent years, the first section ...
Hunt, PH, Khosla, R
core  

Can price transparency contribute to more affordable patient access to medicines? [PDF]

, 2017
No abstract ...
Paterson, Kenneth R., Vogler, Sabine
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Antiretroviral medications for pediatric use in the context of the Unified Health System: are there therapeutic gaps in Brazil? [PDF]

Revista Paulista de Pediatria
Objective: To evaluate the incorporation and adequacy of antiretrovirals for the treatment of HIV in children within the context of the Unified Health System in Brazil.
Suelen Martins da Costa, Patricia Melo Aguiar   +1 more
doaj   +1 more source

A national survey on registered products, availability, prices, and affordability of 100 essential medicines in community pharmacies across Sri Lanka

BMC Health Services Research, 2023
Introduction Availability of essential medicines that meet the expected quality standards, in appropriate dosage forms at affordable prices is a fundamental prerequisite to fulfill healthcare needs of given a population.
Chiranthi Kongala Liyanage, Mekala Gunawardane, Pamodee Panchalee Kumaradasa, Priyanga Ranasinghe, Raveendra Laal Jayakody, Priyadarshani Galappatthy   +5 more
doaj   +1 more source

The Regulatory Review Process in South Africa: Challenges and Opportunities for a New Improved System. [PDF]

, 2018
BACKGROUND: The aims of this study were to assess the regulatory review process in South Africa from 2015 to 2017, identify the key milestones and timelines; evaluate the effectiveness of measures to ensure consistency, transparency, timeliness, and ...
M Cone, M Cone, N McAuslane, R Al-Essa, S Ratanawijitrasin   +4 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source