Results 131 to 140 of about 7,341,045 (287)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Factors associated with maternal practice on Essential Newborn Care in Mekelle City, Tigray, Ethiopia, 2016(n = 373).

, 2018
Factors associated with maternal practice on Essential Newborn Care in Mekelle City, Tigray, Ethiopia, 2016(n = 373).
Tirhas Asmelash Berhea (5675936), Girmatsion Fisseha Abreha (5675942), Abate Bekele Belachew (5675939)   +2 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Newborn Care Practices among Adolescent Mothers in Hoima District, Western Uganda.

PLoS ONE, 2016
IntroductionAdolescent childbearing remains a major challenge to improving neonatal mortality especially in Sub Saharan countries which are still struggling with high neonatal mortality rates.
Lydia Kabwijamu, Peter Waiswa, Vincent Kawooya, Christine K Nalwadda, Monica Okuga, Elizabeth L Nabiwemba   +5 more
doaj   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

Advanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally, Kaustav Bera, Nolan R. Petrich, Alex Khang, Marilyne Coulombe, David Castillo‐Azofeifa, Ophir D. Klein, Peter J. Dempsey, Kristi S. Anseth   +8 more
wiley   +1 more source

Neonatal care readiness for the essential newborn care, neonatal resuscitation, and poor feeding-hypothermia clinical cascades, 2016 and 2017 (N = 23 facilities).

, 2018
Neonatal care readiness for the essential newborn care, neonatal resuscitation, and poor feeding-hypothermia clinical cascades, 2016 and 2017 (N = 23 facilities).
Dilys M. Walker (3846973), John Cranmer (6000407), Peter Waiswa (51296), Phelgona Otieno (5343590), Hilary Spindler (6000398), Grace M. Nalwa (6000404), Melissa C. Morgan (6000395), Harriet Nambuya (6000401), Gertrude Namazzi (491056)   +8 more
core   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Nurturing newborns in South Sudan series: Essential care for the small baby

South Sudan Medical Journal, 2021
“Nurturing newborns in South Sudan” is a series of clinical guidance reviews on newborn care for the South Sudan context. The first part of this series focused on essential care of the newborn giving standard recommendations for the birth, delivery and ...
Isaac Gawar, Grace J. Soma
doaj  

Comparison of overall readiness estimates by stage of care for the essential newborn care, neonatal resuscitation, and poor feeding-hypothermia clinical cascades in 2016 and 2017.

, 2018
Comparison of overall readiness estimates by stage of care for the essential newborn care, neonatal resuscitation, and poor feeding-hypothermia clinical cascades in 2016 and 2017.
Dilys M. Walker (3846973), John Cranmer (6000407), Peter Waiswa (51296), Phelgona Otieno (5343590), Hilary Spindler (6000398), Grace M. Nalwa (6000404), Melissa C. Morgan (6000395), Harriet Nambuya (6000401), Gertrude Namazzi (491056)   +8 more
core   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source