Results 151 to 160 of about 850,915 (318)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ESSENTIAL NORMS OF LINEAR COMBINATIONS OF COMPOSITION OPERATORS ON h∞ [PDF]
, 2013 Kei Ji Izuchi, Kou Hei Izuchi
openalex +1 more source
Boundary vs. interior conditions associated with weighted composition operators
Open Mathematics, 2014 Izuchi Kei, Izuchi Yuko, Ohno Shûichi
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Essential norms of weighted composition operators between Hardy spaces Hpand Hqfor 1≤p,q≤∞ [PDF]
, 2011 Romain Demazeux
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Functional Explanations Link Gender Essentialism and Normativity [PDF]
Why do beliefs that gender differences are innate (i.e., gender essentialism) sometimes lead to normative judgments about how individual people ought to be? In the current study, we propose that a missing premise linking gender essentialism and normativity rests on the common folk-biological assumption that biological features serve a biological ...
Foster-Hanson, Emily, Lombrozo, Tania
openaire
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Coercivity, essential norms, and the Galerkin method for second-kind integral equations on polyhedral and Lipschitz domains [PDF]
, 2021 Simon N. Chandler‐Wilde +1 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source