Results 51 to 60 of about 3,046,243 (224)

Drug Repositioning of Pegbing® for Essential Thrombocythemia: Insights from PK/PD Modeling and Extrapolation

Clinical Pharmacology &Therapeutics, EarlyView.
Pegbing® (peginterferon alfa‐2b), a pegylated interferon‐alpha, is approved for the treatment of chronic hepatitis B (CHB) and C. One of its adverse effects is platelet (PLT) suppression. It is currently being repurposed for the treatment of essential thrombocythemia (ET), a rare myeloproliferative disorder characterized by abnormally elevated PLT ...
Weizhe Jian, Yalin Yin, Rong Chen, Junsheng Xue, Jianbo Gu, Zhengfang Du, Ruoyi He, Tianyan Zhou   +7 more
wiley   +1 more source

Hemorrhage in Essential Thrombocythemia or Polycythemia Vera: Epidemiology, Location, Risk Factors, and Lessons Learned from the Literature

Thrombosis and Haemostasis, 2020
Hemorrhage is a well-known complication of essential thrombocythemia (ET) and polycythemia vera (PV), but evidence-based data on its management and prevention are lacking to help inform clinicians. In this review, appropriate published data from the past
Christophe Nicol, K. Lacut, B. Pan-Petesch, E. Lippert, J. Ianotto   +4 more
semanticscholar   +1 more source

Clinical Application of Using Diffusion‐Based Wasserstein Generative Adversarial Network for Morphologic Analysis of Blood Cells

Journal of Clinical Laboratory Analysis, EarlyView.
This study evaluated the accuracy of blood cell classification using 78,494 images across 13 cell classes, demonstrating a significant improvement with the DWGAN‐GP augmented dataset. The use of synthetic images increased the classification accuracy to 97.74%, outperforming both unbalanced data and commercial systems.
Hyun‐Young Kim, Emmanuel Edward Ngasa, Hee‐Jin Kim, Boram Kim, Gyujin Lim, Chang‐Hun Park, Hyeon Jeong Kwon, Mi‐Ae Jang, Jiyoung Woo   +8 more
wiley   +1 more source

Essential Thrombocythemia and Acquired von Willebrand Syndrome: The Shadowlands between Thrombosis and Bleeding

Cancers, 2020
Over the past decade, new insights have emerged on the pathophysiology of essential thrombocythemia (ET), its clinical management, and associated thrombohemostatic disturbances.
H. Awada, M. Voso, P. Guglielmelli, C. Gurnari   +3 more
semanticscholar   +1 more source

Distinct clinical characteristics of myeloproliferative neoplasms with calreticulin mutations

Haematologica, 2014
Somatic insertions/deletions in the calreticulin gene have recently been discovered to be causative alterations in myeloproliferative neoplasms. A combination of qualitative and quantitative allele-specific polymerase chain reaction, fragment-sizing ...
Hajnalka Andrikovics, Tunde Krahling, Katalin Balassa, Gabriella Halm, Andras Bors, Magdalena Koszarska, Arpad Batai, Janos Dolgos, Judit Csomor, Miklos Egyed, Andrea Sipos, Peter Remenyi, Attila Tordai, Tamas Masszi   +13 more
doaj   +1 more source

The JAK2V617F and CALR mutations and risk of cancer, cardiovascular diseases, and all‐cause mortality

Journal of Internal Medicine, EarlyView.
Abstract Background Clonal hematopoiesis (CH) is associated with adverse outcomes. We hypothesized that CH (JAK2V617F and CALR) is associated with cancer, vascular disease, and all‐cause mortality, even at a variant allele frequency (VAF) <1%. Methods We screened 19,832 individuals from the Danish General Suburban Population Study for JAK2V617F and ...
Morten Kranker Larsen, Vibe Skov, Lasse Kjær, Christina Schjellerup Eickhardt‐Dalbøge, Trine Alma Knudsen, Marie Hvelplund Kristiansen, Anders Lindholm Sørensen, Sabrina Cordua, Troels Wienecke, Mette Grymer Jensen, Morten Andersen, Johnny T. Ottesen, Johanne Gudmand‐Høyer, Jordan Andrew Snyder, Henrik Enghusen Poulsen, Thomas Stiehl, Christina Ellervik, Hans Carl Hasselbalch   +17 more
wiley   +1 more source

Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance TPO is a cytokine that signals through the receptor MPL (or TPO-R), and is essential for megakaryocyte differentiation and maintenance of hematopoietic stem cells (HSCs). TPO signaling is deregulated in essential thrombocythemia (ET).
Lu Cui, Ignacio Moraga, Tristan Lerbs, Camille van Neste, S. Wilmes, N. Tsutsumi, Aaron Claudius Trotman-Grant, Milica Gakovic, Sarah Andrews, J. Gotlib, S. Darmanis, M. Enge, S. Quake, I. Hitchcock, J. Piehler, K. Garcia, G. Wernig   +16 more
semanticscholar   +1 more source

Essential thrombocythemia and acute myocardial infarction treated with rescue coronary angioplasty

Arquivos Brasileiros de Cardiologia, 1999
A 48-year-old man with essential thrombocythemia suffered an extensive anterior acute myocardial infarction; this is a rare association. A pharmacological thrombolysis was performed, without success.
Antonio Esteves Fº, Francisco de Assis Costa, Antonio Augusto Guimarães Lima, Luiz Junya Kajita, Eulógio Emílio Martinez Fº   +4 more
doaj   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Essential Thrombocythemia

Siriraj Medical Journal, 2002
This is a review of twelve cases of Essential Thrombocythemia at Suratthani Hospital, aged between 48 to 87 years old, 6 male and 6 female. The initial clinical presentations were as follows: 2 asymptomatic cases (incidentally found on routine CBC check ...
Kanchanee Janwanitsthaporn
doaj